Suggestions appear as you type. Use the up and down arrows to choose one and Enter to open it.

This page's audience real numbers from our own analytics — open to see them
–Visitors
–Page views
–Clicks to vendors
–Time on page
–Reading now
Clicks to vendors, by tool
  • –
Top countries
  • –
Devices
  • –

– · counted by iTechGuides's own first-party analytics, bots removed, every figure rounded down · how we count

BIOVIA COSMOtherm (COSMO-RS)

#2 of 15 in Chemical Software

BIOVIA COSMOtherm (COSMO-RS): A specialized COSMO-RS tool for predicting molecular properties in pure and mixed liquids. Ranked #2 of 15 in Chemical Software by our editors (7.9/10); pricing: Pricing on request; best for researchers predicting mixture thermodynamics.

7.9/10Editor score
Visit BIOVIA
BIOVIA COSMOtherm (COSMO-RS)7.9 Visit BIOVIA

At a glance

  • Editor score
    7.9 / 10
  • Pricing
    Pricing on request
  • Best for
    Researchers predicting mixture thermodynamics
  • Free plan
    No
  • SDS management
    No
  • Founded
    1981 · Vélizy-Villacoublay, France
  • Facts checked
    24 Sep 2026

  • Where it wins

    • Predicts solubility across liquids, solids and gases
    • Covers phase equilibria, partitioning, vapor pressure and pKa
    • Offers graphical workflows and command-line batch processing

  • Where it doesn't

    • Windows desktop deployment limits platform flexibility
    • Contact-sales pricing makes cost assessment less direct
    • Specialized thermodynamics scope is narrower than process simulation

Our verdict on BIOVIA COSMOtherm (COSMO-RS)

BIOVIA COSMOtherm applies COSMO-RS to predict thermodynamic properties of molecules in pure and mixed liquids. Its intended audience includes researchers and teams in chemistry, chemical engineering, formulation, drug development, environmental science and materials research. The work centers on molecular thermodynamics rather than broad process simulation, making it most relevant when questions concern how compounds behave in mixtures. It is a focused fit for mid-market and enterprise organizations seeking these predictions, rather than a general chemical operations system.

Its feature set spans solubility prediction for liquids, solids and gases, activity coefficients, partitioning, and liquid-liquid, liquid-vapor and liquid-solid phase equilibria. It also calculates vapor pressure, free energy of solvation, Henry’s law predictions, pKa and solvent-dependent reaction equilibria. Conformer populations in mixtures and micelle and membrane partitioning extend the scope to additional molecular contexts. A graphical user interface supports interactive work, while command-line batch processing offers another route for repeatable or workflow-oriented calculations. This breadth within thermodynamic prediction is the product’s central strength; buyers looking for inventory, safety-data-sheet management, formulation management or regulatory compliance should look elsewhere.

COSMOtherm is a Windows desktop product deployed on-premises, so teams should account for that environment when assessing fit. The published pricing model is contact sales, and there is no free plan. Support channels include documentation and community resources. Researchers whose main need is COSMO-RS-based prediction of solubility, partitioning, phase behavior or related molecular properties may find its concentrated scope appropriate. Teams that need a broader process simulator, mobile access, or a different deployment platform should compare alternatives before choosing it.

BIOVIA COSMOtherm (COSMO-RS) pricing

Plans Pricing on request No free plan — trial or paid only. Prices checked 24 Sep 2026.
See plans on 3ds.com

BIOVIA COSMOtherm (COSMO-RS) fact sheet

Free planNo
Paid fromNot verified
SDS managementNo
Chemical inventoryNo
Formulation managementNo
Regulatory complianceNo
DeploymentOn-premises
Mobile accessNo
DeploymentDesktop
PlatformsWindows
SupportCommunity, Docs
Built forMid-market, Enterprise (editorial estimate)
PricingPricing on request
Website3ds.com
Facts checked24 Sep 2026

Alternatives to BIOVIA COSMOtherm (COSMO-RS)

See all BIOVIA COSMOtherm (COSMO-RS) alternatives →

BIOVIA COSMOtherm (COSMO-RS) vs the competition

Compare BIOVIA COSMOtherm (COSMO-RS) with any tool side by side →

Used BIOVIA COSMOtherm (COSMO-RS)? Be the first to review it

The editor score above is our own research. What this page doesn't have yet is a reader's view — what you used BIOVIA COSMOtherm (COSMO-RS) for, what worked and what didn't. No stars are seeded and no review is paid for; an editor reads every one before it appears.

Write a reviewTwo minutes · verified accounts only · read by an editor before it appears

Reviews come only from verified accounts. Sign in or create an account first — your e-mail is never shown.

Your rating

0 characters · at least 80, up to 3,000

Posted from your verified account. Reviews appear after an editor reads them, usually within two working days.

Featured on iTechGuides

Featured on iTechGuides — BIOVIA COSMOtherm (COSMO-RS) 7.9/10

BIOVIA COSMOtherm (COSMO-RS) is listed in our Chemical Software directory. Add the badge to your site — it links back to this page.

<a href="https://www.itechguides.com/products/biovia-cosmotherm-cosmo-rs/"><img src="https://www.itechguides.com/best/badge/biovia-cosmotherm-cosmo-rs.svg" alt="Featured on iTechGuides" width="230" height="46"></a>

Guides on chemical software

Reviewed by iTechGuides Editors · Editorial team · Updated Oct 2026

Advertiser disclosure: iTechGuides is reader-supported. We may earn a commission when you click some links. How we rank.

Last updated · How we research and update