OpenClinica vs Medrio EDC

OpenClinica9.0Visit Medrio EDC8.8Visit

Higher score OpenClinica #3 in Electronic Data Capture Software 9.0/10 30-day trial Free trial✓ 0 of 4 features Visit OpenClinica

vs

Medrio EDC #5 in Electronic Data Capture Software 8.8/10 Pricing on request ✓ 4 of 4 features Visit Medrio

• OpenClinica fits best

  Teams seeking EDC plus consent and trial workflows

• Medrio EDC fits best

  Teams that need offline capture and flexible study building

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Side by side

Feature	OpenClinica 9.0/10 Visit ↗	Medrio EDC 8.8/10 Visit ↗
At a glance
Editor score	9.0	8.8
Ranking	#3 in Electronic Data Capture Software	#5 in Electronic Data Capture Software
Best for	Teams seeking EDC plus consent and trial workflows	Teams that need offline capture and flexible study building
Pricing model	Paid	Paid
Starting price	—	Pricing on request
Free plan	—	—
Free trial	30 days	—
Deployment	Cloud	Cloud
Platforms	Web	Web
Support	Email, Phone, Tickets, Docs	Community
Compliance	SOC 2, ISO 27001, GDPR, HIPAA	SOC 2, ISO 27001, GDPR, HIPAA, SSO/SAML, 2FA
Integrations	1 integrations	4 integrations
Built for	Small business, Mid-market, Enterprise	Small business, Mid-market, Enterprise
Features OpenClinica 0/4 · Medrio EDC 4/4
ePRO support	Not checked yet	✓ (best)
Audit trail	Not checked yet	✓ (best)
Data validation checks	Not checked yet	✓ (best)
Offline data entry	Not checked yet	✓ (best)
Specs
Regulatory compliance	Not checked yet	FDA 21 CFR Part 11; ICH E6(R2); HIPAA; GDPR; Annex 11; ISO 27001; SOC 2
Deployment	Not checked yet	Cloud
Our review
Pros	Combines EDC with eConsent, eCOA, randomization, and EHR integration Validation, workflows, audit trails, and role-based permissions support controlled studies REST API, analytics, and dashboards support programmatic exchange and trial reporting	Build studies and forms with no-code tools, templates, and copying. Capture data offline and monitor it through reports and dashboards. Support data quality with validation, query management, and audit trails.
Cons	Launch limits studies to 150 participants and 3 sites Advanced capabilities depend on higher-tier plans or add-on modules Designed for clinical trials rather than grant-administration workflows	Pricing requires contacting Medrio, making plan costs harder to compare. The listed deployment option is cloud, not an on-premises installation. ePRO support depends on integration with Medrio ePRO.
Our verdict	OpenClinica is a cloud-based electronic data capture and eClinical platform for academic researchers, clinical research organizations, contract research organizations, and clinical research sites. Its core tools include electronic case… Read the review →	Medrio EDC is a cloud-based electronic data capture and data management platform for clinical trials, intended for clinical research teams at small, mid-market, and enterprise organizations. Its no-code, point-and-click tools support study… Read the review →

Strengths and trade-offs

• OpenClinica — where it wins

  • Combines EDC with eConsent, eCOA, randomization, and EHR integration
  • Validation, workflows, audit trails, and role-based permissions support controlled studies
  • REST API, analytics, and dashboards support programmatic exchange and trial reporting

  Where it doesn't

  • Launch limits studies to 150 participants and 3 sites
  • Advanced capabilities depend on higher-tier plans or add-on modules
  • Designed for clinical trials rather than grant-administration workflows

• Medrio EDC — where it wins

  • Build studies and forms with no-code tools, templates, and copying.
  • Capture data offline and monitor it through reports and dashboards.
  • Support data quality with validation, query management, and audit trails.

  Where it doesn't

  • Pricing requires contacting Medrio, making plan costs harder to compare.
  • The listed deployment option is cloud, not an on-premises installation.
  • ePRO support depends on integration with Medrio ePRO.

• OpenClinica9.0/10 · 30-day trial

  A cloud EDC suite that adds consent, outcomes, randomization, analytics, and API-based exchange.

  Visit OpenClinicaFull verdict →
• Medrio EDC8.8/10 · Pricing on request

  A configurable clinical-trial EDC with offline capture, validation, and query management.

  Visit MedrioFull verdict →