Medidata Rave EDC vs OpenClinica

Medidata Rave EDC9.2Visit OpenClinica9.0Visit

Higher score Medidata Rave EDC #1 in Electronic Data Capture Software 9.2/10 Pricing on request ✓ 3 of 4 features Visit Medidata

vs

OpenClinica #3 in Electronic Data Capture Software 9.0/10 30-day trial Free trial✓ 0 of 4 features Visit OpenClinica

• Medidata Rave EDC fits best

  Teams needing a full-featured clinical-trial EDC

• OpenClinica fits best

  Teams seeking EDC plus consent and trial workflows

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Side by side

Feature	Medidata Rave EDC 9.2/10 Visit ↗	OpenClinica 9.0/10 Visit ↗
At a glance
Editor score	9.2	9.0
Ranking	#1 in Electronic Data Capture Software	#3 in Electronic Data Capture Software
Best for	Teams needing a full-featured clinical-trial EDC	Teams seeking EDC plus consent and trial workflows
Pricing model	Paid	Paid
Starting price	Pricing on request	—
Free plan	Not checked yet	—
Free trial	—	30 days
Deployment	Cloud	Cloud
Platforms	Web	Web
Support	Docs	Email, Phone, Tickets, Docs
Compliance	SOC 2, ISO 27001, GDPR, SSO/SAML	SOC 2, ISO 27001, GDPR, HIPAA
Integrations	6 integrations	1 integrations
Built for	Mid-market, Enterprise	Small business, Mid-market, Enterprise
Features Medidata Rave EDC 3/4 · OpenClinica 0/4
ePRO support	✓ (best)	Not checked yet
Audit trail	✓ (best)	Not checked yet
Data validation checks	✓ (best)	Not checked yet
Offline data entry	Not checked yet	Not checked yet
Specs
Regulatory compliance	21 CFR Part 11; ICH E6 (R2); ICH E6 (R3); EU GMP Annex 11; GDPR; ISO 27001; ISO 27701; SOC 2	Not checked yet
Deployment	Cloud	Not checked yet
Our review
Pros	Real-time edit checks and audit trails support controlled trial data workflows. Protocol amendments and mid-study changes can be made without downtime. Connects eCOA, EHR, eConsent, RTSM, imaging and Clinical Data Studio.	Combines EDC with eConsent, eCOA, randomization, and EHR integration Validation, workflows, audit trails, and role-based permissions support controlled studies REST API, analytics, and dashboards support programmatic exchange and trial reporting
Cons	Pricing uses a contact-sales model rather than published numeric plans. Deployment is cloud-based through a web application. Support information lists documentation as the available channel.	Launch limits studies to 150 participants and 3 sites Advanced capabilities depend on higher-tier plans or add-on modules Designed for clinical trials rather than grant-administration workflows
Our verdict	Medidata Rave EDC is a cloud electronic data capture system for biopharmaceutical, medical-device and other clinical studies. It captures site, patient and laboratory data, applies real-time validation checks, supports cleaning and… Read the review →	OpenClinica is a cloud-based electronic data capture and eClinical platform for academic researchers, clinical research organizations, contract research organizations, and clinical research sites. Its core tools include electronic case… Read the review →

Strengths and trade-offs

• Medidata Rave EDC — where it wins

  • Real-time edit checks and audit trails support controlled trial data workflows.
  • Protocol amendments and mid-study changes can be made without downtime.
  • Connects eCOA, EHR, eConsent, RTSM, imaging and Clinical Data Studio.

  Where it doesn't

  • Pricing uses a contact-sales model rather than published numeric plans.
  • Deployment is cloud-based through a web application.
  • Support information lists documentation as the available channel.

• OpenClinica — where it wins

  • Combines EDC with eConsent, eCOA, randomization, and EHR integration
  • Validation, workflows, audit trails, and role-based permissions support controlled studies
  • REST API, analytics, and dashboards support programmatic exchange and trial reporting

  Where it doesn't

  • Launch limits studies to 150 participants and 3 sites
  • Advanced capabilities depend on higher-tier plans or add-on modules
  • Designed for clinical trials rather than grant-administration workflows

• Medidata Rave EDC9.2/10 · Pricing on request

  A broad cloud EDC for multi-site studies needing validation, oversight and connected clinical workflows.

  Visit MedidataFull verdict →
• OpenClinica9.0/10 · 30-day trial

  A cloud EDC suite that adds consent, outcomes, randomization, analytics, and API-based exchange.

  Visit OpenClinicaFull verdict →