Best ThreatLocker Alternatives in 2026
The top ThreatLocker alternatives are Sophos Endpoint, SentinelOne Singularity Endpoint and Microsoft Defender for Business: 15 endpoint protection platforms our editors would look at instead of ThreatLocker, in our ranking order.
ThreatLocker: A control-focused endpoint platform for teams prioritizing application allowlisting. Where it falls short: coverage is limited to windows and macOS..
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Best forTeams wanting balanced endpoint protection
A broad endpoint and EDR suite for teams managing desktops, servers, and devices.
- Exploit blocking
- Device control
- Server protection
9.4/10★★★★★Visit Sophos -
Best forEnterprises needing broad EDR coverage
Broad endpoint, mobile, server and cloud protection with automated response.
- Exploit blocking
- Device control
- Server protection
9.3/10★★★★★Visit SentinelOne -
Best forSmall businesses wanting strong value
Broad device coverage, EDR, and Microsoft integrations at $3 per user monthly.
9.1/10★★★★★Visit site -
Best forOrganizations needing comprehensive controls
A broad endpoint security suite for organizations needing prevention, detection and policy control.
- Exploit blocking
- Device control
- Server protection
9.0/10★★★★☆Visit Check Point -
Best forMixed-OS teams needing strong endpoint fundamentals
A broad endpoint security suite for mixed-OS teams that need centralized control.
- Exploit blocking
- Device control
- Server protection
8.9/10★★★★☆Visit ESET -
Best forTeams needing endpoint and cloud controls
A broad endpoint security suite for teams that need controls beyond malware protection.
- Exploit blocking
- Device control
- Server protection
8.8/10★★★★☆Visit Kaspersky Next -
Best forFortinet-centered security teams
A broad endpoint security client for teams built around the Fortinet ecosystem.
8.7/10★★★★☆Visit FortiClient -
Best forBudget-conscious mixed-platform teams
Broad endpoint coverage and strong containment at a low annual per-device price.
- Exploit blocking
- Device control
- Server protection
8.6/10★★★★☆Visit Comodo -
Best forMature teams needing server protection
A broad, centrally managed security suite for teams protecting endpoints, servers, email, and gateways.
- Exploit blocking
- Device control
- Server protection
8.4/10★★★★☆Contact Doctor Web -
Best forTeams wanting cloud or on-premises control
A centrally managed security subscription for mixed desktop, mobile, and server environments.
8.2/10★★★★☆Visit ESET -
Best forWindows-focused endpoint teams
A feature-rich Windows endpoint suite for teams that need centralized control.
- Device control
- Behavioral protection
- Central management console
8.1/10★★★★☆Visit AhnLab -
Best forTeams prioritizing zero-day prevention
A prevention-first platform for teams focused on zero-day and ransomware defense.
- Exploit blocking
- Server protection
- Behavioral protection
8.0/10★★★★☆Visit Deep Instinct -
Best forTeams wanting lightweight managed endpoint AV
A focused endpoint security suite for teams that want managed protection across broad platforms.
7.8/10★★★★☆Visit ThreatDown -
Best forMSPs needing endpoint protection and patching
A layered endpoint security and patching platform built for MSP administration.
- Central management console
7.6/10★★★★☆Visit Heimdal -
Best forTeams needing cloud endpoint administration
Broad cloud endpoint controls for IT teams managing distributed devices.
7.5/10★★★★☆Visit Seqrite
ThreatLocker Alternatives: Common Questions
What is the best alternative to ThreatLocker?
Sophos Endpoint: #1 in our Endpoint Protection Platforms ranking, with an editor score of 9.4 out of 10. A broad endpoint and EDR suite for teams managing desktops, servers, and devices.
ThreatLocker vs Each Alternative
| # | Tool | Free plan | Paid from | Supported operating systems | Behavioral protection | Exploit blocking | Central management console | Score |
|---|---|---|---|---|---|---|---|---|
| 13 | ThreatLocker | No | — | — | Yes | Yes | Yes | 7.9 |
| 1 | Sophos Endpoint | No | — | — | Yes | Yes | Yes | 9.4 |
| 2 | SentinelOne Singularity Endpoint | No | $179.99/device/yr | — | Yes | Yes | Yes | 9.3 |
| 3 | Microsoft Defender for Business | No | $3/user/mo | — | — | — | — | 9.1 |
| 4 | Check Point Harmony Endpoint | — | — | — | Yes | Yes | Yes | 9.0 |
| 5 | ESET Endpoint Security | No | — | — | Yes | Yes | Yes | 8.9 |
| 6 | Kaspersky Next | — | — | — | Yes | Yes | Yes | 8.8 |
| 7 | FortiClient | No | — | — | — | — | — | 8.7 |
| 8 | Comodo Advanced Endpoint Protection | No | $4/device/mo | — | Yes | Yes | Yes | 8.6 |
| 9 | Dr.Web Enterprise Security Suite | No | — | — | Yes | Yes | Yes | 8.4 |
| 10 | ESET PROTECT Entry | No | — | — | — | — | — | 8.2 |
| 11 | AhnLab V3 Endpoint Security | — | — | Windows | Yes | — | Yes | 8.1 |
| 12 | Deep Instinct Prevention Platform | — | — | — | Yes | Yes | Yes | 8.0 |
| 14 | ThreatDown Endpoint Protection | — | — | — | — | — | — | 7.8 |
| 15 | Heimdal Security | — | — | — | — | — | Yes | 7.6 |
| 16 | Seqrite Endpoint Protection Cloud | — | — | — | — | — | — | 7.5 |
Guides on Endpoint Protection Platforms
- Top Linux Endpoint Protection Software in 2026: Best Picks by Use CaseAug 2026
- Gartner’s Historical 11 Best Endpoint Protection Platforms, Ranked by Customers (CRN)Sep 2026
- The 5 Best Free Endpoint Protection Solutions for Windows in 2026Aug 2026
Reviewed by iTechGuides Editors · Editorial team · Updated Oct 2026
Last updated · How we research and update