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A squishy mouse might let your hand grip a computer mouse more upright, but the Fleximouse and its follow-on A-frame design are research prototypes—not proven treatments or established retail products. The idea is to change how the hand rests on a mouse; the available reporting does not show that either design reduces pain or prevents injury.

What are the Fleximouse prototypes?

Fleximouse: a deformable shell

The project calls its original concept “Fleximouse.” It has a mesh-like, flexible shell that deforms when squeezed, exploring a different approach from a conventional hard, fixed mouse shape. The project repository links research materials and STL files, but those files and links do not establish that a complete mouse is available to buy. The project repository

The A-frame: a follow-on design

According to Hackster.io’s report, the first flexible version was too fragile for daily use. Jose Berengueres, working with Tony Yu at the University of Melbourne’s School of Design, then developed an A-frame hinge concept intended to preserve a palmar-grip approach while being more robust and easier to manufacture. The report says its fit remains sensitive to hand size, suggesting that different sizes or adjustability may be needed.

Why make a mouse squishy or more upright?

The ergonomic rationale is grip orientation, not softness for its own sake. The Hackster report compares the intended upright hand position with vertical mice: moving away from a flat grip is meant to reduce forearm pronation and crossover. That is the designers’ rationale, not proof that these prototypes relieve wrist symptoms.

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#1 Best Overall
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Logitech Lift Vertical Ergonomic Wireless Mouse - Graphite
  • Lift yourself up: When the desk life gets you down, lift yourself up with Logitech Lift Vertical Ergonomic Mouse - a great fit for small to medium right hands
  • Raise your hand into comfort: Rest on Lift upright mouse throughout the day, with a softly textured grip and snug thumb rest for level-above coziness
  • 57 degrees of sooooothe: Lift’s vertical shape helps wrists feel like “ahhh” at work, and promotes a more natural posture in the forearm, for day-long comfort and productivity
  • Relax into focus: Settle into work with a wireless computer mouse featuring easy-to-reach customizable buttons, whisper-quiet clicks, and a SmartWheel for smooth, seamless scrolling
  • Ergo-certified: Lift wireless vertical mouse has been designed, developed, tested, and approved according to criteria set out by leading ergonomists

Berengueres told Hackster that “The flat, rigid shape of today’s mouse forces the hand into an unnatural position” and that “Over time, this causes continuous stress on the forearm and wrist.” Those are his claims about the design problem; the reporting does not establish them as clinical findings for every user.

Do the designs prevent wrist pain or injury?

That has not been demonstrated in the available sources. They describe design intent and prototype limitations, but do not report a controlled comparison, clinical outcome, sample size, or evidence that either prototype prevents injury or treats pain. A more upright grip may be worth considering as a comfort preference, but it should not be presented as a medical solution.

Rank #2
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ProtoArc EM11 NL Wireless Ergonomic Vertical Mouse, Rechargeable, Black
  • Perfect Fit for Small to Medium Hands: Designed specifically for hand lengths under 7.5 inches (19.05 cm), the EM11 NL reduces wrist strain by aligning with your natural grip. Please measure the size before ordering for a better fit and more comfort
  • Connect up to 3 Devices: This ergonomic wireless mouse features dual Bluetooth connectivity and 2.4G USB-A connectivity modes for simultaneous connection of up to 3 different devices, and is compatible with Windows 8, Windows 10 or higher, Mac OS X 10.12 or higher, and Android 4.3 or higher
  • Rechargeable Ergonomic Mouse: The Bluetooth Vertical Mouse has a built-in 500mAh Li-Ion battery that can be conveniently recharged using the included Type-C cable(The Type-C cable is for charging only)
  • Ergonomic Vertical Design: The ergonomic mouse wireless keeps your wrist naturally straight, putting your forearm and wrist in a more natural and relaxed position, which can reduce discomfort and strain, helping to improve productivity and reduce the risk of repetitive strain injuries compared to a standard mouse. Warm tips: We encourage you to relax your palm and hold the mouse naturally when using a vertical mouse
  • Learning curve: Since it takes a learning curve to get used to the shape when using our ergonomic mouse for the first time, it may cause inconvenience to your mouse grip, We recommend that you take 1-2 weeks to get used to it, as many users find that it will help reduce the pressure and pain on your wrist caused by long-term use of the mouse and improve comfort

The project repository repeats two computer-use complaint figures, attributing them to Basakci Calik and colleagues’ 2022 paper: 20% of computer users with at least one chronic disorder related to computer use, and roughly 50% with at least one complaint in the prior 12 months. These are figures stated by the project authors, not measurements from the Fleximouse project; the underlying paper’s population and definitions are not verified here. Project repository and references

Can you buy a Fleximouse?

The available project materials do not establish that either prototype is sold as a finished mouse. The repository links STL files and research materials, which may interest people exploring the design, but file availability is not the same as a ready-to-use product. It also discloses a provisional patent application, US Provisional Application No. 63/768,137, filed March 6, 2025, and labels the work patent pending; that is the project’s disclosure, not independent verification of current patent status.

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Anker 2.4G Wireless Ergonomic Mouse, Right Hand Vertical Mouse USB Receiver
  • Experience enhanced comfort and productivity with the Anker 2.4G Wireless Vertical Ergonomic Optical Mouse. Its scientifically designed ergonomic structure promotes a healthy neutral "handshake" wrist and arm position, reducing strain and amplifying your productivity.(Uses 2.4 GHz wireless via a USB receiver, not Bluetooth.)
  • Enjoy superior sensitivity and precision with this wireless mouse. It boasts 800/1200/1600 DPI Resolution Optical Tracking Technology, offering more sensitivity than standard computer mice. This ensures smooth and precise tracking on a diverse range of surfaces, making it ideal for both work and leisure activities.
  • The Anker Ergonomic Mouse is not only convenient but also user-friendly. It comes with next/previous buttons for effortless webpage browsing, making it an excellent choice for internet enthusiasts, gamers, and those who spend prolonged periods on their computer. Note: Key click sounds are unavoidable.
  • This computer mouse is not just ergonomic but also energy-efficient and durable. It transitions into a power-saving mode after 8 minutes of inactivity, entirely disconnecting power. A simple press of the right or left button wakes it up. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
  • The package offers a comprehensive set and warranty. It includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (stored in the mouse's bottom), 1 instruction manual. We extend an 18-month hassle-free warranty for your peace of mind.
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What can you use now?

If you want to try a more upright grip, an ergonomic vertical mouse is an existing product category with a similar rationale. It is separate from the Fleximouse prototypes, and the cited reporting does not establish that vertical mice provide a medical benefit. Compare options by orientation, hand-size fit, adjustability, and durability rather than assuming that a particular shape will work for everyone. No named model, price, or clinical performance comparison is established by the available reporting.

Quick Recap

SaleBestseller No. 4
Logitech MX Vertical Wireless Mouse Ergonomic Design - Graphite
Logitech MX Vertical Wireless Mouse Ergonomic Design - Graphite
(1) As compared with a traditional mouse with 1000 DPI sensor; Uses FSC-certified paper for responsible packaging
$77.99
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TECKNET Ergonomic Mouse, 4800 DPI Wireless Bluetooth Vertical, 3-Device
  • 【Seamless Switching Between Three Devices】The ergonomic mouse features Bluetooth (5.0/3.0) and 2.4GHz USB A modes for connectivity. When connected via Bluetooth, The vertical mouse can effectively reduce the usage of your USB-A port (Bluetooth mode can connect to two devices simultaneously). In 2.4GHz connection mode, simply plug in the USB receiver for a quick connection. Press and hold the bottom button of the mouse for 3 seconds to enter the connection and pairing state. Short press the button to switch connection modes and improve work efficiency.(Note: The 2.4GHz receiver is built into the bottom of the mouse).
  • 【Higher DPI & 6 Adjustable Levels】This vertical ergonomic mouse is equipped with a high-performance chip and features 6 adjustable DPI levels (4800/3200/2400/1600/1200/800) to meet your daily needs. wireless mouse upgraded technology allows this ergonomic mouse to operate smoothly on different types of surfaces. When changing the DPI, the light will flash, with the number of flashes corresponding to the DPI level.
  • 【Silent Mouse】This computer mouse operates quietly, allowing for usage even in quiet environments like libraries. Additionally, the vertical mouse provides nearly silent clicks, helping avoid disturbances to others and ensuring your work or study remains undisturbed (Note: Only the left and right click buttons of the mouse are silent; other function buttons are not silent).
  • 【Ergonomic Design】The wireless mouse's ergonomic design offers ultimate comfort by placing your palm at a near-vertical angle on the desktop, reducing pressure and pain on your wrist caused by prolonged inverted mouse usage (Note: Mouse is designed for right-handed use only).
  • 【Broad Compatibility and Low Battery Warning】The wireless computer mouse is compatible with various devices, including Windows, Mac, Chrome, and Linux laptops (side buttons are not compatible with macOS). Additionally, this bluetooth mouse for laptops automatically enters deep sleep mode after approximately 10-30 minutes of inactivity to conserve power; you can awake it by pressing the right or left button. Note: We recommend using branded batteries to ensure the mouse's longevity. When the battery is low, the LED light will blink (Requires 2 AAA batteries, not included).
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Logitech MX Vertical Wireless Mouse Ergonomic Design - Graphite
  • NATURAL HANDSHAKE POSITION - MX Vertical’s natural handshake position reduces muscular activity by 10 percent compared to a standard mouse – without any loss in overall performance
  • 57° VERTICAL ANGLE FOR IMPROVED WRIST POSTURE - MX Vertical’s unique 57° vertical angle reduces the pressure on your wrist, while your thumb is positioned comfortably on the thumb rest
  • USER TESTED. ERGONOMIST-APPROVED. MX Vertical has been designed and tested with criteria set out by leading ergonomists – improve posture, lower muscle strain, and reduce wrist pressure
  • ADVANCED OPTICAL TRACKING WITH CURSOR SPEED SWITCH- The 4000 DPI high-precision sensor results in 4x less hand movement (1) and reduces fatigue. The cursor speed switch instantly adjusts DPI speed and accuracy with the touch of a button
  • (1) As compared with a traditional mouse with 1000 DPI sensor

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