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Candida auris (also called Candidozyma auris) is a yeast that can live on a person without causing symptoms or cause serious infection. It is especially difficult to manage because it spreads in healthcare facilities, can persist on people and surfaces, and is often resistant to antifungal medicines. A positive screening result alone does not mean someone has an infection that should be treated.
What is Candida auris?
Candida auris, abbreviated C. auris, is a type of yeast. It may colonize a person’s skin or other body sites without making them ill, or it may cause a clinical infection. The distinction matters: colonization means the organism is present, while clinical infection means it is causing illness.
CDC says most strains are resistant to at least one type of antifungal medicine. The organism can also be difficult for laboratories to identify accurately without specialized methods. See the CDC overview of C. auris.
Why is C. auris difficult to treat?
Resistance can limit effective medicines
Resistance to antifungal drugs is common, and some strains resist all three major classes of antifungal medicines. CDC’s December 15, 2025 U.S. summary reports that over 90% of U.S. C. auris samples were resistant to fluconazole. Echinocandin-resistant infections were less than 1% in that U.S. summary, but CDC says they were increasing. Those figures describe the United States, not a worldwide rate.
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Echinocandins remain CDC’s recommended initial treatment for most clinical infections in people older than two months. If resistance is suspected or the patient does not improve, clinicians may use susceptibility testing, monitor closely, and consider alternatives. Evidence for treating echinocandin-resistant and pan-resistant infections is limited, so there is no single proven regimen for every such case. CDC’s clinical treatment guidance describes these decisions.
A positive test may indicate colonization, not disease
A test can detect C. auris in a person who has no signs or symptoms of infection. Detection at a noninvasive site, including the respiratory tract or urine, does not by itself establish clinical disease. CDC states that patients without signs or symptoms of infection should not be treated for C. auris. Treatment decisions depend on clinical assessment, not screening positivity alone.
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Identification and susceptibility testing need specialized lab methods
Accurate identification may require sequencing or mass spectrometry; CDC describes MALDI-TOF mass spectrometry as the most reliable identification method. The Clinical and Laboratory Standards Institute has not established C. auris-specific breakpoints for interpreting susceptibility tests. CDC provides tentative breakpoints for interim use, which means results require expert interpretation alongside the patient’s condition.
How does C. auris spread in healthcare settings?
C. auris spreads readily among patients in healthcare facilities. A person may carry it for a long time, potentially indefinitely, and contaminate nearby items and surfaces such as bedrails, doorknobs, and blood-pressure cuffs. Shared patient-care equipment can also contribute to spread if it is not properly cleaned and disinfected.
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Healthcare facilities use infection-control measures for both colonized and infected patients. CDC guidance includes hand hygiene, appropriate precautions, thorough daily and terminal room cleaning, and cleaning and disinfection of reusable equipment after use. Facilities should choose products with EPA-registered claims for C. auris and communicate a patient’s status when transferring or referring them. These are healthcare infection-control recommendations, not a recommendation to use a particular household cleaner. See CDC infection-control guidance and the EPA list of registered antimicrobial products effective against C. auris.
Independent reader supportYour contribution helps us test, update, and keep practical guides available for everyone.How is a C. auris infection treated?
Treatment is clinician-directed and depends on the patient’s age, clinical condition, infection site and severity, susceptibility results, and response to therapy. CDC guidance dated April 24, 2024 recommends an echinocandin initially for clinical infections in adults and children older than two months. For infants younger than two months, the initial recommendation is amphotericin B deoxycholate; if the infant does not respond, liposomal amphotericin B may be considered.
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| Situation | CDC guidance |
|---|---|
| Colonization or detection without signs or symptoms of infection | Do not treat the positive result alone; maintain appropriate infection-control precautions. |
| Clinical infection in adults and children older than two months | An echinocandin is the recommended initial treatment. |
| Clinical infection in infants younger than two months | Amphotericin B deoxycholate is recommended initially; liposomal amphotericin B may be considered if the infant does not respond. |
| Echinocandin resistance or no improvement after five days | CDC advises considering liposomal amphotericin B, with treatment guided by the clinician and susceptibility testing. |
| Pan-resistant infection | Evidence is limited; an infectious-disease specialist may consider investigational drugs in particular cases. |
CDC advises considering infectious-disease consultation, patient-specific factors, susceptibility testing, and close monitoring. These recommendations are for healthcare providers; antifungal treatment should not be started or changed without a clinician.
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What should a patient or caregiver understand about a positive result?
- Ask the care team whether the result represents colonization or clinical infection, and what signs or symptoms support that assessment.
- Ask how the facility is applying precautions and cleaning shared equipment and the patient’s care area.
- If the patient is transferred or referred to another facility, ensure the care team communicates the C. auris status.
- Do not try to treat a screening result with over-the-counter antifungals or supplements; a positive result without symptoms is not itself an indication for treatment.
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