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Clean Invisalign aligners regularly using the method your orthodontist recommends. Invisalign patient instructions describe gently brushing the aligners with a soft-bristled toothbrush, water and a small amount of toothpaste, then rinsing thoroughly. Remove trays before eating or drinking anything other than tap water, store them in their case, and brush your teeth before putting them back in.

How to clean Invisalign aligners day to day

  1. Remove the aligners. Take them out before cleaning and set them somewhere clean while you prepare.
  2. Brush gently. Invisalign patient instructions describe using a soft-bristled toothbrush, water and a small amount of toothpaste.
  3. Rinse thoroughly. Rinse away residue before reinserting the aligners. The manufacturer instructions also say to rinse under warm running water if a toothbrush or cleaning system is unavailable. Follow your orthodontist’s directions if they differ; the available patient-instruction PDF is an older revision. Read Invisalign’s patient instructions.

Use warm or cool water, not hot water. Heat can damage aligners; Invisalign’s Cleaning Crystals+ product instructions specifically caution against hot water.

Eating, drinking and reinserting your aligners

Remove your aligners before eating or drinking anything other than tap water. The American Association of Orthodontists (AAO) gives this guidance and recommends brushing your teeth before reinserting aligners. Invisalign’s patient instructions likewise say to remove trays for eating and drinking, while allowing cool or tepid water. See the AAO food and drink FAQ.

After a meal or other drink, clean your teeth before putting the trays back in. Keep your case with you when you leave home so you have a safe place for aligners while eating. Your orthodontist can advise what to do if brushing is not practical in a particular situation.

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#1 Best Overall
INVISALIGN Cleaning Crystals | Aligner and Retainer Cleaner | 50 Packets
  • Get Your Invisalign Cleaner in 15 Minutes: With 50 packets included, these special cleaning crystals for Invisalign retainers work in 15 minutes to remove plaque from your aligners or retainers to keep them odor-free, hygienic and clear
  • Easy to Use: Weekly, remove aligners and rinse; Place them in a container; Fill with warm water to immerse; Add a packet of Invisalign crystals; Agitate for 20 seconds to dissolve; Let stand for 15 minutes; Agitate for 20 seconds; Rinse thoroughly
  • Best Storage Practices for Your Invisalign Cleaner Crystals: Keep these packets of clear aligner cleaner in a cool, dry place to ensure optimal usability
  • Ingredients: Sodium Sulfate, Sodium Carbonate, Sodium Tripolyphosphate, Sodium Dichlorosocyanurate, Sodium Lauryl Sulfate
  • Invisalign Value: From cases to retainer cleaners, Invisalign offers all the tools and Invisalign accessories you need to maximize the experience of achieving your best smile; Aligners not included

How to store aligners when they are out

Put removed aligners in their case rather than leaving them loose on a table, wrapping them in a napkin or placing them in a pocket. A case helps keep them together and protected while they are not being worn. Follow your provider’s instructions for any additional cleaning or storage steps.

Are Invisalign Cleaning Crystals+ necessary?

No. Cleaning Crystals+ is an optional branded cleaning method, not a universal requirement. Invisalign describes it as a no-brush soak; routine brushing and rinsing are also described in the company’s patient instructions. Choose a method that matches your orthodontist’s advice and the directions for the specific product or cleaner.

Rank #2
INVISALIGN Cleaning Crystals+ | Aligner and Retainer Cleaner | Mint
  • ALIGNER AND RETAINER CLEANER: Keep your aligners or retainer's odor-free, hygienic, and clean with our Invisalign aligner and retainer Cleaning Crystals+
  • EASY TO USE: Just pour one capful of Cleaning Crystals+ into a container of water, add aligners, let soak for 15 minutes. No need to brush, just rinse
  • SIMPLIFY CLEANING: Use daily to keep aligners clean and clear. 60-day supply
  • INNOVATIVE FORMULATION WITH MINT: Oxygen-based cleaning powder that helps clean aligners and remove stuck-on stains. Leaves aligners clean and clearer with each use as well as minty fresh
  • DEEPER CLEAN: For an even deeper clean, use the Cleaning Crystals+ with our Invisalign Ultrasonic Cleaner

Using Cleaning Crystals+

  1. Add one capful of crystals to 100 ml of warm water.
  2. Fully submerge the aligners and stir for 20 seconds.
  3. Soak for 15 minutes, then rinse the aligners thoroughly.

Invisalign’s product instructions say, “Soak aligners or retainers in the mixture for 15 minutes.” These directions apply to Cleaning Crystals+, not to every aligner-cleaning product. The product page says not to use hot water. Check the current Cleaning Crystals+ instructions.

What the product’s bacteria claim means

Align Technology reports a 99.99% reduction in five named odor-causing bacterial strains after a 15-minute exposure, based on third-party testing with data on file as of December 12, 2023. This is a product-test result, not a clinical outcome or evidence that the product eliminates all bacteria.

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Rank #3
Retainer Cleaner Tablets, Denture Cleaner, Mint, 4 Month Supply by M3
  • Dentist-Developed Formula: Our M3 Extra Strength Retainer Cleaning Tablets feature a dentist-developed, laboratory-tested deep cleaning formula that helps restore clarity by removing tough stains, buildup, and unwanted odors from retainers, dentures, and other removable dental appliances.*
  • 120 Tablets of Optimal Results: Our denture cleaning tablets provide the most complete cleansing solution on the market. Each tablet is individually sealed for convenient storage and use, helping remove discoloration, stains, plaque, stubborn odors, and tartar!* Eligible for purchase with qualifying FSA and HSA funds for added convenience!
  • All Dental Appliances: Our tablets are perfect for denture baths, retainers, dentures, aligners, Invisalign, mouth guards, night guards, snore guards, sport guards, TMJ devices, and other removable dental appliances!*
  • Easy to Use: Just drop one tablet into warm water with your dental appliance and let our extra strength cleanser do the rest. Use with a denture bath, denture cup, denture case, or ultrasonic retainer cleaner machine for convenient soaking and cleaning. Achieve the best results by helping remove food particles, cloudy film, and plaque buildup. Quickly restore any dental appliance in just minutes!*
  • About Our Brand: M3 is a brand that contains products that contain natural ingredients and other ingredients. However, all M3 items are quality tested in the USA with the highest standards.

Choosing between brushing, crystals and an ultrasonic cleaner

The options differ in how they are used; the available sources do not establish that one cleans better than another in a direct comparison.

Method Brushing Time or routine Practical consideration
Soft-bristled toothbrush, water and a small amount of toothpaste Yes Brush gently, then rinse thoroughly; a specific duration is not stated in the Invisalign patient instructions. Does not require a soaking product; follow your orthodontist’s instructions.
Invisalign Cleaning Crystals+ No, according to Invisalign 20 seconds of stirring and a 15-minute soak, followed by thorough rinsing. Requires the product and warm water; use only as directed for this product.
Invisalign ultrasonic cleaner Not stated on the listing Not stated on the listing. Invisalign’s US accessory store lists it for clear aligners and Vivera retainers. Check its current directions and your provider’s advice. View the ultrasonic cleaner listing.
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When your provider’s directions differ

Follow the cleaning and wear instructions from the orthodontist treating you. The AAO notes that providers should give patients specific aligner-cleaning guidance, and individual treatment instructions take priority over a general routine. Ask your provider before using a cleaning product or device if you are unsure it is suitable for your aligners.

Best Value
Retainer Cleaner Tablets for Invisalign Approved for Ultrasonic Cleaners -120 Denture Cleaning Tablets for Aligners, Night Guard, Mouth Guard - Denture Cleaner Tablets 4-Month Supply
  • ✅ FSA & HSA APPROVED, WORKS WITH ULTRASONIC CLEANERS – Take advantage of FSA/HSA benefits on your oral care routine. Our premium retainer cleaning tablets are approved for use as dental pod tablets, ultrasonic cleaner tablets, and dental pod ultrasonic cleaner for retainers. Compatible with zima dental pod ultrasonic cleaner, these premium tablets offer professional-level cleaning you can trust.
  • 🦷 DENTIST RECOMMENDED, SAFE FOR ALL DENTAL APPLIANCES – Our premium dental appliance cleaner tablets is trusted by professionals and safe for aligners, invisalign, night guards, mouthguards, dentures, veneers, flippers, and more. Use confidently with mouthguard cleaners, night guard cleaner tablets, and even ultrasonic denture cleaner systems.
  • ⚡ EXTRA STRENGTH DEEP CLEANING IN JUST 5 MINUTES – Experience next-level freshness with our premium retainer cleaner tablets, formulated for fast, deep cleaning in as little as 5 minutes. These ultrasonic boosting tablets dissolve plaque, food particles, and stains on all dental appliances with no scrubbing required.
  • 🧪 KILLS 99.9% OF ODOR-CAUSING BACTERIA – Eliminate bacteria that causes bad breath, buildup, and cloudiness. These premium retainer cleaning tablets function as night guard cleaner, mouth guard cleaner tablets, and invisalign cleaner tablet, perfect for daily cleaning or deep soaking in dental pod ultrasonic cleaners.
  • 🌱 MINT FRESHNESS WITH CRYSTAL-CLEAR RESULTS – Our premium dental cleaning tablets deliver a refreshing mint scent while restoring appliance clarity. Works great as aligner cleaner tablets, invisalign cleaner, and even cleaning crystals for Invisalign retainers—leaving your appliance fresh, bright, and residue-free.
Rank #4
INVISALIGN Cleaning Crystals System with Tub | Aligner and Retainer Cleaner
  • Get Your Invisalign Cleaner in 15 Minutes: With 50 packets and a cleaning tub included, these cleaning crystals for Invisalign retainers work in 15 minutes to remove plaque from your aligners or retainers to keep them odor-free, hygienic and clear
  • Easy to Use: Weekly, remove aligners and rinse; Place them in a tub; Fill with warm water to immerse; Add a packet of Invisalign crystals; Agitate for 20 seconds to dissolve; Let stand for 15 minutes; Agitate for 20 seconds; Rinse thoroughly
  • Best Storage Practices for Your Invisalign Cleaner Crystals: Keep these packets of clear aligner cleaner in a cool, dry place to ensure optimal usability
  • Ingredients: Sodium Sulfate, Sodium Carbonate, Sodium Tripolyphosphate, Sodium Dichlorosocyanurate, Sodium Lauryl Sulfate
  • Invisalign Value: From cases to retainer cleaners, Invisalign offers all the tools and Invisalign accessories you need to maximize the experience of achieving your best smile; Aligners not included

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