In the United States, most adults should get two doses of Shingrix starting at age 50. Adults age 19 and older who are, or will be, immunocompromised because of a disease or treatment should also get two doses. The usual interval is 2–6 months; some immunocompromised adults may get dose two after 1–2 months when earlier completion is useful.
Who should get the shingles vaccine?
Adults age 50 and older
CDC recommends two doses of Shingrix, also called recombinant zoster vaccine (RZV), for immunocompetent adults age 50 and older. The recommendation applies even if you have had shingles before or previously received Zostavax. CDC does not recommend routine screening or laboratory testing for prior varicella in this age group. CDC: Shingles vaccine recommendations
Adults age 19 and older who are immunocompromised
CDC also recommends two doses for adults age 19 and older who are, or will be, immunodeficient or immunosuppressed because of a disease or therapy. This includes people anticipating immunosuppressive treatment as well as those already receiving it. CDC: Shingles vaccination for immunocompromised adults
How far apart should the two doses be?
Usual schedule: 2–6 months apart
For both groups, dose two is usually given 2–6 months after dose one. CDC: Shingles vaccine recommendations
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An immunocompromised adult who would benefit from finishing sooner may receive dose two 1–2 months after the first. CDC gives avoiding a period of more intense immunosuppression as an example of why earlier completion may be helpful. If you are receiving or preparing for immunosuppressive treatment, coordinate timing with the clinician managing your condition or therapy; when possible, CDC advises vaccination before immunosuppression. CDC: Shingles vaccination for immunocompromised adults
What if dose two is late?
If more than six months have passed since dose one, get the second dose as soon as possible. You do not need to restart the series. CDC: Shingles vaccine recommendations
What if you have had shingles or Zostavax?
After a shingles episode
There is no specific waiting period after a prior shingles episode, but do not get Shingrix during an acute episode. Wait until the acute illness has ended and symptoms have abated. CDC: Shingles vaccine recommendations
After Zostavax
Shingrix is still recommended after a previous Zostavax dose. Wait at least eight weeks after Zostavax before receiving Shingrix. Zostavax is no longer available in the United States. CDC: Shingles vaccine recommendations
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What to expect from Shingrix
CDC reports that Shingrix is over 90% effective against shingles and postherpetic neuralgia in adults age 50 and older with healthy immune systems. That estimate is specific to that group and should not be generalized to every immunocompromised population. CDC estimates that about 1 in 3 people in the United States will have shingles during their lifetime. CDC: Shingles vaccination
Common reactions include a sore arm, redness or swelling, tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea. They usually go away on their own within 2–3 days. CDC advises getting dose two even if you had these reactions after dose one. CDC: Recombinant Zoster Vaccine VIS
Tell the vaccination provider if you have had a severe allergic reaction to a vaccine or a previous Shingrix dose, currently have shingles, or are pregnant; the provider may decide to postpone vaccination. If you are moderately or severely ill, you should usually wait until you recover. A minor illness such as a cold does not necessarily require postponement. Shingrix may be given alongside other adult vaccines at different anatomical sites. CDC: Recombinant Zoster Vaccine VIS CDC: Shingles vaccine recommendations
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