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Treat the result as an unverified research claim until its computational workflow and, where relevant, its hardware measurements have been checked. Preserve the original run, reconstruct exactly what executed, rerun with controlled inputs and recorded settings, and have the derivation and analysis checked independently. A failed reproduction is a reason to investigate—not, by itself, proof of fraud, error, or a discovery.

What does “unreproducible” mean here?

First distinguish two different checks. The National Academies’ 2019 report Reproducibility and Replicability in Science uses reproducibility for obtaining consistent computational results with the same inputs, methods, code, and analysis conditions. Replicability asks whether the research question holds when new data are obtained. A rerun of an analysis and a fresh set of quantum-device measurements therefore test different things.

Nor does “different” always mean “wrong.” A software workflow may be expected to reproduce the same result under fixed conditions, while quantum measurement outcomes can vary between runs. The meaningful question is whether the observed difference changes the scientific conclusion under an appropriate, stated criterion—not simply whether every output bit matches.

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What should the team do first?

  1. Pause the claim and preserve the original run. Save the agent’s prompt and response, accessible system instructions, tool configuration and call logs, model or service version if known, timestamps, code, inputs, output files, and any human edits. Preserve raw measurement counts and job metadata before rerunning or cleaning up files.
  2. Reconstruct what actually ran. Identify the backend or simulator, submitted circuit, transpiled circuit, layout and routing, compiler and optimization settings, shot count, mitigation or postselection, calibration context, and analysis code. An abstract circuit is not necessarily the circuit sent to a device: transpilation maps it to the device’s instructions and topology, and its choices affect the resulting physical circuit.
  3. Repeat the original computational workflow. Use the recorded inputs, code, dependencies, environment, and settings. Record seeds wherever supported. For Qiskit transpilation, the official guide identifies seed_transpiler as the argument for setting the pseudorandom-number-generator seed when reproducible compiler output is needed. Record the SDK and compiler versions too; versioned records help make clear which behavior was used.
  4. Separate a software check from a hardware check. First determine whether the same software pipeline produces the expected circuit and analysis outputs. Then, if hardware measurement is part of the claim, repeat measurements and retain each run’s raw outcomes and execution context. Do not treat a new device run as if it were merely a rerun of deterministic post-processing.
  5. Have the work checked independently. Ask a quantum-domain researcher to inspect the derivation, circuit, measured observable, units, and analysis. Where feasible, check small instances against known results, a simulator, a separate implementation, or an appropriate verification experiment. State explicitly when classical resources or the available methods limit verification.
  6. Document and report the discrepancy. Compare the original and rerun conditions and outputs, describe diagnostic attempts, and state the current confidence level. Do not silently discard failed runs or select only the output that supports the expected conclusion.

What belongs in a reproducibility package?

The National Academies recommends providing clear, specific, complete information about computational methods and data products so others can repeat an analysis, subject to restrictions such as nonpublic-data policies. Its report identifies input data, detailed methods and computational steps with parameters, and information about the original computational environment. For an agent-assisted quantum result, the record also needs details about the agent and quantum execution.

  • Agent and workflow: agent identity and version, prompt, accessible system instructions, tool configuration and logs, and human edits.
  • Software environment: repository URL and immutable commit or archive, code, dependencies, compiler and SDK versions, operating system, hardware or simulator configuration, and an environment lockfile or container image where feasible.
  • Scientific specification: mathematical statement, circuit source, measurement definition, parameter values, input data, pseudorandom seeds, and the expected output or tolerance.
  • Executed quantum job: transpiled circuit, pass configuration, layout and routing, target backend, job ID and timestamp, shots, and mitigation or postselection settings.
  • Evidence and analysis: raw counts or measurement data, intermediate files, calibration metadata and timestamp, analysis code, plots, and the exact procedure used to derive the claimed result.
  • Known limits: identify provider internals, private data, calibration snapshots, nondeterministic components, or computing resources that are inaccessible or prevent an independent rerun.

IBM Research describes Qiskit Experiments as providing characterization, calibration, and verification experiments. Record the relevant calibration context and its timestamp rather than treating a device as unchanged across executions.

How should two runs be compared?

Record the comparison criterion before interpreting the mismatch. “Same” can mean identical files, the same compiled circuit, an unchanged scientific conclusion, or agreement within a predeclared tolerance; those are not interchangeable.

Comparison axis What to check Why it matters
Workflow Inputs, code, dependencies, environment, and analysis A change in any of these means the rerun was not a strictly controlled computational reproduction.
Compiler Compiler version, seed, pass configuration, layout, routing, and transpiled circuit Transpilation choices can change the physical circuit even when the abstract circuit is unchanged.
Hardware context Backend and relevant calibration context; raw outcomes retained for each job A new execution may have a different device context, and aggregate output alone can conceal variation.
Outcome criterion Bitwise identity, same conclusion, or agreement within a stated statistical tolerance The appropriate standard depends on whether the result is deterministic computation, stochastic compilation, or measurement.
Independent check Separate researcher, implementation, simulator, or verification test Agreement across methods can strengthen confidence, while each method’s limits still need to be stated.

Do not demand bitwise-identical measurement records when the process is inherently stochastic. Instead, define what agreement would support the scientific claim and evaluate repeated outcomes against that criterion. If the result depends on sampling, explain the statistical basis for the tolerance rather than choosing one after seeing which output is favorable.

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How should the discrepancy affect the claim?

A mismatch can point to a methodological or software problem, hardware variation, an analysis mistake, or an unexpected result. It does not identify its own cause. Follow the evidence: if a code or derivation error is found, correct the record; if the discrepancy remains unexplained or the provenance is incomplete, keep the claim preliminary and seek independent review. If it survives checks, describe it as a candidate result requiring further validation rather than presenting reproducibility as established.

Report the original output, the rerun conditions, what differed, what was checked, and what remains uncertain. The National Academies’ reproducibility guidance supports transparent reporting of computational methods and data products; it does not establish a single universal journal policy for every discrepancy.

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What if the agent’s work cannot be reconstructed?

If the agent cannot explain its work or key records are missing, do not infer that the result is valid from a plausible response. State which parts cannot be independently checked and lower the claim’s confidence accordingly. Check the requirements of the particular journal, funder, and institution for AI-agent contribution or disclosure; no single current rule can be assumed to apply everywhere. In any venue, clearly describe the agent’s contribution and the human validation actually performed.

No established statistic here gives the rate at which AI agents produce unreproducible quantum results. A team should therefore report its own evidence and avoid implying a field-wide failure rate.

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