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Yes—some Arduino boards can act as USB-to-TTL serial adapters, but only when their USB-to-serial bridge is connected to UART pins you can access and the target’s signal voltage is compatible. On an Uno Rev3, for example, pins 0 (RX) and 1 (TX) provide 5 V UART serial. Connect TX to the other device’s RX, RX to its TX, and join the grounds. Before wiring, check whether the board’s main microcontroller shares those pins; it can interfere with the connection.

How the Arduino-to-USB serial connection works

A USB connector by itself does not make an Arduino a USB-to-TTL converter. The board needs circuitry that bridges USB to a UART, and that UART must be accessible to the target device. Arduino support distinguishes AVR-based UNO R3, Mega, and classic Nano boards with dedicated USB-to-serial chips from boards where the main microcontroller handles the USB connection. Board families and revisions differ, so verify the exact model’s manual or schematic before wiring.

The Uno Rev3 manual provides a specific example: its ATmega328 communicates over 5 V UART on pins 0 and 1, and an on-board ATmega8U2 connects that serial interface to a virtual COM port. This is an Uno example, not a pinout or voltage rule for every Arduino. Arduino Uno Rev3 manual; Arduino upload troubleshooting.

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How to wire the UART

For a board with an accessible USB-to-UART bridge, connect the serial signals crossed and share a ground:

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  • Arduino bridge TX to target RX.
  • Arduino bridge RX to target TX.
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Confirm the target’s permitted UART logic levels before connecting. The Uno example uses 5 V UART; do not connect its TX signal directly to a target that accepts only a lower voltage. Use appropriate level conversion when required. Also check the target’s power needs rather than assuming the Arduino’s power pin can safely supply it. Arduino Uno Rev3 manual; FTDI TTL-232R cable range.

Check for interference from the Arduino’s main MCU

On some boards, the primary microcontroller and the USB bridge both connect to the UART pins. The Uno documentation, for example, describes the UART as used by both the ATmega328 and the USB bridge. If the main MCU drives or loads the lines, it may contend with the target and prevent reliable serial communication.

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There is no universal way to isolate the main MCU: the safe procedure depends on the board design. Consult the exact schematic. Removing a socketed MCU or holding a chip in reset may be possible on some boards, but neither should be treated as a general recipe. If you cannot establish a safe way to isolate the UART, use a dedicated adapter instead.

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Serial communication and bootloader reset are separate

TX and RX carry serial data; they do not, by themselves, ensure that a target enters its bootloader or resets at the right time. Arduino’s platform specification explains that DTR or RTS control signals from a USB-to-TTL adapter can be converted by board circuitry into a reset pulse to activate the bootloader during an upload. Arduino states, “The auto-reset system is necessary to activate the bootloader at the start of an upload.” That applies to upload reset behavior, not to ordinary UART communication in general. Arduino CLI platform specification.

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If the target must reset or enter a particular boot mode for an upload, check its documentation and confirm that the required control signal is exposed and wired correctly. A manual reset or target-specific boot procedure may be necessary; do not assume the Arduino bridge will reset another device automatically.

Test the serial path with Arduino’s loopback procedure

Arduino documents a loopback test for UNO R3 and older revisions, UNO R3 SMD, Mega2560 Rev3 and older, Mega ADK Rev3, and classic Nano. It checks whether data sent from the computer returns through the board’s serial path.

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  1. Disconnect USB and all external connections.
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  3. Reconnect USB, open Serial Monitor, send a message, and check whether it is echoed.

Arduino warns that this test always fails on CH340-based derivative boards. A failed test on one of those boards therefore does not establish that its interface is damaged. Arduino loopback test instructions.

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If uploads to the Arduino itself stop working after connecting a target, Arduino support recommends removing connections from digital pins 0 (RX) and 1 (TX) while troubleshooting; attached circuitry on those pins can interfere with uploads. Arduino upload troubleshooting.

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When a dedicated USB-to-TTL adapter is the better choice

A dedicated adapter avoids relying on an Arduino board’s particular bridge and shared-UART design. FTDI’s TTL-232R cable range, for example, is designed to connect TTL-level serial devices to USB using an FT232R USB/UART interface. Its cable variants have different I/O electrical characteristics, so confirm the specific adapter’s levels and signal pins rather than relying on the product family name. FTDI TTL-232R cable range.

What to check Using an Arduino board Using a dedicated USB-to-TTL adapter
USB-to-UART path Confirm the exact board has a bridge connected to accessible UART pins; designs differ. Arduino support Check the selected adapter’s documented USB/UART interface. FTDI
Logic voltage Check the board’s UART level; the Uno Rev3 example is 5 V. Arduino Uno manual Check the exact adapter variant’s I/O levels. FTDI
Shared UART or MCU isolation May need board-specific isolation if the main MCU shares the lines. Not dependent on isolating an Arduino MCU.
Reset control Do not assume DTR/RTS is exposed or suitable for the target. Check whether the adapter exposes the control signals the target requires.

Choose based on the target’s logic voltage, required TX/RX/GND and reset-control signals, operating-system driver support for the exact adapter, and whether the Arduino’s main MCU can be safely isolated. A dedicated adapter is generally the cleaner option for voltage-sensitive targets, reliable bootloader uploads, or boards whose shared UART cannot be isolated safely. USB-to-TTL UART and RS-232 are different electrical interfaces; an RS-232 adapter is not interchangeable with a TTL-UART adapter.

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