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Head-to-head · Endpoint Security Software

ESET PROTECT Enterprise vs Microsoft Defender for Business

  • Updated Oct 2026
  • Both researched from official sources
  • 6 checks side by side
Higher score ESET PROTECT Enterprise #4 in Endpoint Security Software 9.0/10 Pricing on request · 30-day trial ✓ 5 of 5 features Visit ESET
Microsoft Defender for Business #7 in Endpoint Security Software 8.7/10 From $3/user/mo (annual) · 30-day trial ✓ 1 of 5 features Visit Microsoft

ESET PROTECT Enterprise leads on 4 checks, Microsoft Defender for Business on 0, and 2 are even. Who comes out ahead on the 6 yes/no, price and count checks where we have data for both products. The editor score weighs everything else too.

Our verdict

  • Highest scoreESET PROTECT Enterprise · 9.0/10
  • Most featuresESET PROTECT Enterprise · 5 of 5

ESET PROTECT Enterprise scores higher on our rubric for endpoint security software: 9.0 against 8.7 out of 10; our editors rank them #4 and #7.

ESET PROTECT Enterprise offers edr included; Microsoft Defender for Business doesn't publish it. ESET PROTECT Enterprise offers xdr included; Microsoft Defender for Business doesn't publish it. ESET PROTECT Enterprise offers mobile protection; Microsoft Defender for Business doesn't publish it. ESET PROTECT Enterprise offers server protection; Microsoft Defender for Business doesn't publish it.

ESET PROTECT Enterprise is the better fit for enterprises securing endpoints, mobile devices and workloads. Microsoft Defender for Business is the better fit for small businesses seeking low-cost endpoint protection.

  • ESET PROTECT Enterprise fits best

    Enterprises securing endpoints, mobile devices and workloads

  • Microsoft Defender for Business fits best

    Small businesses seeking low-cost endpoint protection

Advertiser disclosure: iTechGuides is reader-supported. Vendors can pay for top positions in our rankings and for a place on other products' pages, and we may earn a commission when you click some links. How we rank.

Side by side

Feature ESET PROTECT Enterprise 9.0/10 Visit ↗ Microsoft Defender for Business 8.7/10 Visit ↗
At a glance
Editor score 9.0 8.7
Ranking #4 in Endpoint Security Software #7 in Endpoint Security Software
Best for Enterprises securing endpoints, mobile devices and workloads Small businesses seeking low-cost endpoint protection
Pricing model Paid Paid
Starting price Not published $3/user/mo
Free plan — —
Free trial — —
Free trial length 30 days · no card needed 30 days · card required
Deployment Cloud, Self-hosted Cloud, Mobile
Platforms Web, Windows, macOS, Linux, iOS, Android Web, Windows, macOS, iOS, Android
Support Email, Live chat, Phone, Tickets, Community, Docs · 24/7 Docs
Built for Enterprise Small business, Mid-market
Features ESET PROTECT Enterprise 5/5 · Microsoft Defender for Business 1/5
EDR included ✓ (best) Not published
XDR included ✓ (best) Not published
Mobile protection ✓ (best) Not published
Server protection ✓ (best) Not published
Ransomware protection ✓ ✓
Specs
Supported platforms Windows, macOS, Linux, Android, iOS, AWS, Azure, GCP Windows, macOS, iOS, Android
Entry-plan endpoint limit Not published Not published
Our review
Pros
  • Covers computers, smartphones, servers and cloud virtual machines
  • Combines EDR/XDR, sandboxing, encryption and mobile threat defense
  • Offers cloud or self-hosted console deployment
  • Combines antivirus, EDR, ransomware disruption, and automated remediation
  • Includes vulnerability management and attack-surface reduction rules
  • Supports Windows, macOS, iOS, and Android, with Intune integration
Cons
  • Enterprise pricing requires a customized offer
  • The 30-day trial is for PROTECT Advanced, not Enterprise
  • The broad feature set may exceed needs for endpoint-only teams
  • Standalone subscription is limited to five devices per user
  • Annual billing is required for the stated $3-per-user monthly price
  • A payment card is required for the 30-day free trial
Our verdict

ESET PROTECT Enterprise brings endpoint, mobile, server and cloud workload protection into one subscription for enterprises managing varied device types. It covers Windows, macOS, Linux, Android and iOS endpoints, as well as virtual…

Read the review →

Microsoft Defender for Business is endpoint security for small and medium-sized businesses. The standalone subscription supports up to 300 users and five devices per user, making it a fit for smaller organizations that want protection…

Read the review →
  1. ESET PROTECT EnterpriseEndpoint Security Software 9.0Pricing on request · 30-day trial
  2. Microsoft Defender for BusinessEndpoint Security Software 8.7From $3/user/mo (annual) · 30-day trial

Strengths and trade-offs

  • ESET PROTECT Enterprise — where it wins

    • Covers computers, smartphones, servers and cloud virtual machines
    • Combines EDR/XDR, sandboxing, encryption and mobile threat defense
    • Offers cloud or self-hosted console deployment

    Where it doesn't

    • Enterprise pricing requires a customized offer
    • The 30-day trial is for PROTECT Advanced, not Enterprise
    • The broad feature set may exceed needs for endpoint-only teams
  • Microsoft Defender for Business — where it wins

    • Combines antivirus, EDR, ransomware disruption, and automated remediation
    • Includes vulnerability management and attack-surface reduction rules
    • Supports Windows, macOS, iOS, and Android, with Intune integration

    Where it doesn't

    • Standalone subscription is limited to five devices per user
    • Annual billing is required for the stated $3-per-user monthly price
    • A payment card is required for the 30-day free trial
  • ESET PROTECT Enterprise9.0/10 · Pricing on request · 30-day trial

    Broad endpoint, mobile and workload protection with XDR and flexible deployment.

    Visit ESETFull verdict →
  • Microsoft Defender for Business8.7/10 · From $3/user/mo (annual) · 30-day trial

    A $3-per-user endpoint security subscription with antivirus, EDR, and ransomware response.

    Visit MicrosoftFull verdict →

More comparisons

Guides on endpoint security software

Reviewed by iTechGuides Editors · Editorial team · Updated Oct 2026

Last updated · How we research and update