Head-to-head · Endpoint Security Software
ESET PROTECT Enterprise vs Microsoft Defender for Business
ESET PROTECT Enterprise leads on 4 checks, Microsoft Defender for Business on 0, and 2 are even. Who comes out ahead on the 6 yes/no, price and count checks where we have data for both products. The editor score weighs everything else too.
Our verdict
- Highest scoreESET PROTECT Enterprise · 9.0/10
- Most featuresESET PROTECT Enterprise · 5 of 5
ESET PROTECT Enterprise scores higher on our rubric for endpoint security software: 9.0 against 8.7 out of 10; our editors rank them #4 and #7.
ESET PROTECT Enterprise offers edr included; Microsoft Defender for Business doesn't publish it. ESET PROTECT Enterprise offers xdr included; Microsoft Defender for Business doesn't publish it. ESET PROTECT Enterprise offers mobile protection; Microsoft Defender for Business doesn't publish it. ESET PROTECT Enterprise offers server protection; Microsoft Defender for Business doesn't publish it.
ESET PROTECT Enterprise is the better fit for enterprises securing endpoints, mobile devices and workloads. Microsoft Defender for Business is the better fit for small businesses seeking low-cost endpoint protection.
- ESET PROTECT Enterprise fits best
Enterprises securing endpoints, mobile devices and workloads
- Microsoft Defender for Business fits best
Small businesses seeking low-cost endpoint protection
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Side by side
| Feature | ESET PROTECT Enterprise 9.0/10 Visit ↗ | Microsoft Defender for Business 8.7/10 Visit ↗ |
|---|---|---|
| At a glance | ||
| Editor score | 9.0 | 8.7 |
| Ranking | #4 in Endpoint Security Software | #7 in Endpoint Security Software |
| Best for | Enterprises securing endpoints, mobile devices and workloads | Small businesses seeking low-cost endpoint protection |
| Pricing model | Paid | Paid |
| Starting price | Not published | $3/user/mo |
| Free plan | — | — |
| Free trial | — | — |
| Free trial length | 30 days · no card needed | 30 days · card required |
| Deployment | Cloud, Self-hosted | Cloud, Mobile |
| Platforms | Web, Windows, macOS, Linux, iOS, Android | Web, Windows, macOS, iOS, Android |
| Support | Email, Live chat, Phone, Tickets, Community, Docs · 24/7 | Docs |
| Built for | Enterprise | Small business, Mid-market |
| Features ESET PROTECT Enterprise 5/5 · Microsoft Defender for Business 1/5 | ||
| EDR included | ✓ (best) | Not published |
| XDR included | ✓ (best) | Not published |
| Mobile protection | ✓ (best) | Not published |
| Server protection | ✓ (best) | Not published |
| Ransomware protection | ✓ | ✓ |
| Specs | ||
| Supported platforms | Windows, macOS, Linux, Android, iOS, AWS, Azure, GCP | Windows, macOS, iOS, Android |
| Entry-plan endpoint limit | Not published | Not published |
| Our review | ||
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| Cons |
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| Our verdict | ESET PROTECT Enterprise brings endpoint, mobile, server and cloud workload protection into one subscription for enterprises managing varied device types. It covers Windows, macOS, Linux, Android and iOS endpoints, as well as virtual… Read the review → |
Microsoft Defender for Business is endpoint security for small and medium-sized businesses. The standalone subscription supports up to 300 users and five devices per user, making it a fit for smaller organizations that want protection… Read the review → |
Strengths and trade-offs
ESET PROTECT Enterprise — where it wins
- Covers computers, smartphones, servers and cloud virtual machines
- Combines EDR/XDR, sandboxing, encryption and mobile threat defense
- Offers cloud or self-hosted console deployment
Where it doesn't
- Enterprise pricing requires a customized offer
- The 30-day trial is for PROTECT Advanced, not Enterprise
- The broad feature set may exceed needs for endpoint-only teams
Microsoft Defender for Business — where it wins
- Combines antivirus, EDR, ransomware disruption, and automated remediation
- Includes vulnerability management and attack-surface reduction rules
- Supports Windows, macOS, iOS, and Android, with Intune integration
Where it doesn't
- Standalone subscription is limited to five devices per user
- Annual billing is required for the stated $3-per-user monthly price
- A payment card is required for the 30-day free trial
- ESET PROTECT Enterprise9.0/10 · Pricing on request · 30-day trial
Broad endpoint, mobile and workload protection with XDR and flexible deployment.
Visit ESETFull verdict → - Microsoft Defender for Business8.7/10 · From $3/user/mo (annual) · 30-day trial
A $3-per-user endpoint security subscription with antivirus, EDR, and ransomware response.
Visit MicrosoftFull verdict →
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Guides on endpoint security software
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- Best Small Business Endpoint Security Options for 2026, Based on Independent TestsOct 2026
Reviewed by iTechGuides Editors · Editorial team · Updated Oct 2026
Last updated · How we research and update


