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Scientists found DNA from sheeppox virus in parchment from the approximately 1,000-year-old York Gospels and other medieval manuscripts. The finding shows that animal-skin pages can preserve traces of disease; it does not mean the books were infected, and there is no evidence that sheeppox infects people.

What disease DNA did scientists find?

The researchers detected genetic material from sheeppox virus (SPPV), a pathogen that affects sheep. University College Dublin (UCD) identifies the York Gospels as one example, alongside the Corpus Glossary at Corpus Christi College, Cambridge, and other medieval codices from Britain and continental Europe. The institutional accounts describe the York Gospels as about 1,000 years old.

The finding was reported in a study led by UCD and the Helmholtz Institute for One Health, published in Science Advances on September 4, 2026: L’Hôte et al., “Three thousand five hundred years of sheeppox virus evolution inferred from archaeological and codicological genomes,” volume 12, issue 36, article eaeh3571, DOI 10.1126/sciadv.aeh3571. UCD’s account and the Helmholtz Institute for One Health report describe the findings.

How can an old book contain virus DNA?

Medieval parchment is made from animal skin. DNA traces from the animal material—and potentially from pathogens associated with it—can remain in the parchment. As lead author Louis L’Hôte put it in the institute’s report, “Here we show that parchment can also preserve animal pathogen DNA.”

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Detecting DNA in a page is not the same as finding an active virus or showing that the manuscript itself had an infection. It is evidence that parchment can preserve biological traces, much as archaeological animal remains can preserve evidence of past disease.

What does the discovery tell us about sheeppox history?

The manuscript evidence forms part of a longer timeline, not a claim that the virus began in medieval Europe. The study also examined ancient sheep teeth from Bronze Age pastoralist settlements in the Eurasian steppe. The Helmholtz Institute describes the reconstructed SPPV history as more than 3,500 years; UCD says sheeppox has affected Eurasian sheep herds for at least 3,700 years. Those are distinct summaries of the study’s timeline.

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The accounts separately estimate that major capripoxvirus lineages—including sheeppox, goatpox, and lumpy skin disease virus—diverged between 11,500 and 3,700 years ago. That broader range concerns lineage divergence, not the age of the York Gospels or the earliest direct evidence cited for SPPV.

Why was sheeppox DNA found on different animal skins?

Researchers reported SPPV DNA on parchment identified as sheep, calf, and goat skin. The accounts leave open two explanations: rare cross-species infection, or transfer of material during parchment-making. The DNA finding alone does not establish which explanation is correct.

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Can sheep pox infect people?

The reporting states there is no evidence that sheep pox infects humans. The discovery concerns traces of an animal pathogen in historical parchment; it is not evidence of a human health risk.

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