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Usually, no—not completely or reliably. Biofertilizers can improve how plants access nutrients and may help reduce some mineral fertilizer in a well-matched crop and management system. Current evidence supports using them as part of integrated nutrient management, not as a universal one-for-one replacement.

What biofertilizers do—and what they do not do

Biofertilizers are preparations containing live or dormant microorganisms applied to seed or soil. Their activity can make nutrients more available to plants. Depending on the organism, they may fix atmospheric nitrogen, help solubilize or mobilize nutrients such as phosphorus, or produce substances that promote plant growth. The FAO technical document on biofertilizers and its plant nutrition publication describe these functions.

That is different from applying a measured dose of mineral fertilizer: a microbial input relies on living organisms becoming active in the crop and soil. It may help plants use nutrients already present or supplied from other sources, but it does not deliver a predictable quantity of each nutrient by itself.

What the evidence says about yields

A global meta-analysis of 171 peer-reviewed publications by Schütz and colleagues reported the following pooled yield responses to biofertilization by climate. These are averages across studies, not guaranteed results for an individual farm.

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Climate category Pooled yield response reported in the 2018 meta-analysis
Dry +20.0 ± 1.7%
Tropical +14.9 ± 1.2%
Oceanic +10.0 ± 3.7%
Continental +8.5 ± 2.4%

The figures describe pooled study results, not a fertilizer-replacement rate. The authors also found that yield response was generally small where soil phosphorus was low. Arbuscular mycorrhizal fungi had greater success in soils with low organic matter and neutral pH. Results therefore depend on the crop, climate, soil and microbial group—not simply on whether a product is labeled a biofertilizer. See the 2018 meta-analysis record in FAO AGRIS.

When partial fertilizer substitution may work

Integrated nutrient management combines sources such as mineral fertilizer, organic materials and biofertilizers to meet crop needs. In one FAO example, pulse production combines farmyard manure, Rhizobium inoculation and 50% of the recommended NPK; the practice is described as saving 50% of chemical fertilizer. That result belongs to this specific example. It is not a general rate for other crops, soils or locations. The example appears in FAO’s resource on improving plant nutrient management.

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Rhizobium can contribute biologically fixed nitrogen when paired with a compatible legume. Other inoculants may help plants access nutrients in the soil or from organic materials. Whether that contribution allows a grower to reduce mineral fertilizer must be determined for the specific crop and local conditions.

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Why results vary

Effectiveness is crop- and location-specific. FAO identifies several factors that can affect microbial activity and crop response:

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  • Competition with microorganisms already present in the soil.
  • Poor aeration, high temperature or unsuitable soil moisture.
  • Soil acidity, salinity or alkalinity, and toxic elements.
  • Product viability, shelf life, handling, storage and carrier-material limitations.

Compatibility and inconsistent efficacy are also concerns in the USDA Agricultural Research Service review, “Microbial inoculants for optimized plant nutrients use in integrated pest and input management systems.” The USDA ARS-hosted review states: “Microbial inoculants cannot replace chemical fertilizers now or in the immediate future.” A 2024 review record also identifies limited and inconsistent field efficacy as a commercialization challenge: Fadiji et al. in FAO AGRIS.

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How to use biofertilizers without over-reducing nutrients

  1. Match the organism to the crop. Check that the inoculant is intended for the crop in question; Rhizobium products, for example, are relevant to compatible legumes.
  2. Check local conditions and nutrient status. Use soil testing and locally appropriate nutrient recommendations to guide any fertilizer adjustment. A yield response reported elsewhere does not establish a safe reduction for your field.
  3. Follow the product label. Observe its directions for storage, handling, timing and application so the microorganisms have a chance to remain viable and reach the crop as intended.
  4. Adjust fertilizer only within a suitable plan. Treat an inoculant as one part of an integrated program, and base any reduction on crop-specific local guidance rather than a broad percentage claim.