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A 2021 pilot study detected chemical signals in blood samples from pregnant women and newborns and tentatively identified 55 compounds that the authors said had not previously been reported in the literature. The finding does not mean all 55 were confirmed, newly created, or shown to harm babies: the study screened for chemicals and did not test health effects.

What the researchers did

Wang and colleagues used liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QTOF/MS), a high-resolution analytical method, to screen a database of about 3,500 industrial chemicals. They analyzed 30 matched pairs of maternal serum and umbilical cord serum from San Francisco—60 samples in total—in a proof-of-concept study published in Environmental Science & Technology in March 2021. Read the study.

The team compared detected signals with chemical databases, then used fragmentation patterns to prioritize and tentatively identify suspects. The paper reports 73 tentatively identified suspects. Using analytical standards, the researchers confirmed 17 chemical features corresponding to 15 unique compounds.

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What “55 previously unreported” means

The authors wrote that they “tentatively identified 55 compounds not previously reported in the literature.” “Tentatively” matters: these were not all confirmed compound identities. The phrase “not previously reported in the literature” describes the authors’ literature comparison; it does not establish that the chemicals had never been present in people or had never existed.

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Confirmation requires comparing a sample against an analytical standard for the substance. The authors note that standards are also needed to assess toxicity. As UCSF co-lead author Dimitri Panagopoulos Abrahamsson put it, identifying more chemicals is only part of the task; standards are needed to confirm their presence and evaluate toxicity. UCSF’s summary of the study also reports 109 chemicals detected overall, including 55 described as not previously reported in people.

Examples and gaps in what is known

Examples among the 55 in the paper include the plasticizer Sumilizer GA 80 and two PFAS compounds: methyl perfluoroundecanoate and 2-perfluorooctyl ethanoic acid. The paper also describes a high-production-volume chemical used in consumer products such as fragrances. These examples do not establish how any individual participant encountered a chemical.

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Both the paper and UCSF emphasize that source and use information is limited for many of the compounds. UCSF says 37 of the 55 had little to no information about sources or uses. The paper separately discusses 42 compounds with limited-to-no information before excluding compounds previously reported in human exposure studies; those are differently framed counts, not interchangeable totals.

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UCSF’s overview groups detected chemicals by reported use, including 40 used as plasticizers, 28 in cosmetics, 25 in consumer products, 29 as pharmaceuticals, 23 as pesticides, three as flame retardants, and seven PFAS compounds. These categories can overlap, and a reported use does not prove a participant’s exposure came from that use.

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What the study does—and does not—say about babies’ health

The analysis established chemical detections and prioritized possible identities in a small set of matched samples. It did not measure illness, development, or other health outcomes, and it did not determine whether any detected compound caused harm. Finding a chemical in maternal and cord serum is not, by itself, evidence of a health effect or a specific exposure route.

The authors said the number of poorly characterized chemicals in maternal and cord samples warrants further investigation into possible sources and health effects. That is a call for research, not a result showing that these compounds injured the newborns. The study’s 30 pairs from San Francisco also cannot be treated as a representative estimate for all pregnant people or newborns.

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Why the result matters

The study illustrates both the reach and the limits of modern chemical screening: high-resolution methods can flag substances that targeted testing or existing literature may not cover, but suspect matches need confirmation and toxicity information before their implications can be judged. Tracey J. Woodruff, the UCSF professor quoted in the institutional account, said that some chemicals may have been in people for a long time and are now easier to identify with newer technology.

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Because the study did not identify actionable household sources or evaluate interventions, it does not support buying a particular consumer product as a protective response. Its central contribution is evidence that researchers found many chemical signals worth confirming and characterizing, while important questions about identity, source, and health effects remain open.

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