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In a 2023 Phase 2 trial, adults taking the highest studied dose of retatrutide lost an average of 24.2% of their body weight over 48 weeks. That result is promising, but it is not a prediction for any one person—and retatrutide is still investigational, not an approved medicine you can buy.
How much weight did retatrutide help people lose?
The “quarter of your weight” figure comes from a 2023 Phase 2 trial published in the New England Journal of Medicine. The Eli Lilly-funded study enrolled 338 adults with obesity or overweight who did not have type 2 diabetes. At 48 weeks, the least-squares mean weight change was −24.2% among participants assigned to 12 mg retatrutide, compared with −2.1% with placebo.
| Trial group | Mean weight change at 48 weeks |
|---|---|
| Retatrutide 12 mg | −24.2% |
| Combined retatrutide 8-mg groups | −22.8% |
| Combined retatrutide 4-mg groups | −17.1% |
| Retatrutide 1 mg | −8.7% |
| Placebo | −2.1% |
These are group averages from that trial, not guaranteed individual outcomes. At 48 weeks, 83% of participants in the 12-mg group had lost at least 15% of their starting weight; the corresponding figure in the placebo group was 2%.
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In a 2026 company report on the TRIUMPH-2 Phase 3 study, Lilly said adults with type 2 diabetes and obesity or overweight who received 12 mg lost an average of 20.8% of their body weight—reported as 49.6 lb—at 80 weeks. Lilly said the results were presented at the European Association for the Study of Diabetes meeting and published in The Lancet. They are company-reported Phase 3 results and remain subject to regulatory review.
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The Phase 2 and Phase 3 figures should not be read as a direct comparison. They come from studies with different populations and follow-up periods, and the Phase 2 participants did not have type 2 diabetes.
How is retatrutide supposed to work?
Retatrutide, also called LY3437943, is an investigational once-weekly injection developed by Eli Lilly. It is a triple hormone receptor agonist: one molecule activates receptors for GIP, GLP-1, and glucagon. These pathways are being studied for their roles in appetite and glucose regulation; glucagon activity is also being investigated for possible effects on energy expenditure and metabolism.
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The mechanism does not establish that retatrutide is superior to approved medicines. That conclusion would require appropriate comparative evidence and regulatory review.
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In the Phase 2 trial, gastrointestinal adverse events were the most common. They were dose-related and mostly mild to moderate. The researchers also observed dose-dependent increases in heart rate, which peaked around week 24 and declined afterward. These findings describe what was observed in the trial; they do not establish the full safety profile for routine or long-term use.
The trial reported improvements in exploratory cardiometabolic measures, including blood pressure, glycated hemoglobin, fasting glucose, insulin, and lipids other than HDL cholesterol. These are exploratory findings, not proof that retatrutide prevents heart attacks, strokes, or other complications.
Is retatrutide approved, and where can you get it?
No. Eli Lilly says retatrutide has not been approved by the FDA or any other regulatory agency. Lilly’s medically reviewed explainer states: “It has not been approved by any regulatory agency and no one should take anything claiming to be retatrutide outside of a Lilly-sponsored clinical trial.” The company says it is legally available only through its sponsored clinical trials.
Do not buy products online that claim to be retatrutide. Outside an authorized trial, the identity, purity, and dose of such products cannot be verified. No legitimate Amazon product currently represents retatrutide itself.
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Is retatrutide better than Ozempic or Mounjaro?
The available figures do not answer that question. The retatrutide results above come from its own trials, not a head-to-head comparison with semaglutide (sold as Ozempic for certain uses) or tirzepatide (sold as Mounjaro for certain uses). Trial populations, treatment duration, dosing, and study design can all differ, so comparing headline percentages across separate studies can be misleading.
Retatrutide is also investigational, whereas approved medicines have regulatory status and prescribing information that retatrutide does not yet have. A clinician can discuss approved options in light of a patient’s health, treatment goals, and medical history.
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When might retatrutide be available, and what will it cost?
There is no established retail availability or price in the information currently reported here. The 2026 Phase 3 results are subject to regulatory review; they do not by themselves mean the drug is approved or available to prescribe. No current patient-support program, insurance coverage, or public signup route is established.
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