Cleo Autonomous Coding review
Autonomous acute-care coding with linked evidence, coder routing and EHR integrations.
Reviewed by iTechGuides Editors · Editorial team · Updated Nov 2026
Cleo Autonomous Coding is a cloud AI medical-coding solution for emergency and hospital medicine teams. It accepts secure PDF or TIFF chart uploads, or connects through an EHR, then extracts diagnoses, procedures and medical-decision-making signals. The system assigns CPT, ICD-10-CM, ICD-10-PCS and DRG codes, supports both professional-fee and facility coding, and produces ready-to-bill output for revenue-cycle workflows. Its stated company-size fit is mid-market and enterprise organizations.
The published Free pilot provides up to 100 charts coded at no cost, with a BAA signed before kickoff and codes, evidence and MDM breakdown on the organization’s data. Commercial pricing uses a contact-sales model. EHR integrations include Epic, Oracle Cerner, athenahealth, NextGen, eClinicalWorks, Meditech and Modernizing Medicine, giving the product a defined path into established clinical systems. Secure chart upload provides an alternative when direct integration is not the preferred starting point.
A notable strength is the evidence trail: each assigned code is linked to supporting chart text, while charts requiring subjective judgment are routed to coders for review. Operational tracking covers DRG mix, CMI movement and documentation trends, extending the product beyond code assignment into ongoing revenue-cycle monitoring. Cleo is a strong fit for acute-care organizations seeking autonomous coding across multiple code sets with human escalation available. Teams coding outside emergency and hospital medicine, or requiring a non-cloud deployment or support channels beyond email, should evaluate alternatives.
Questions about Cleo Autonomous Coding
Does Cleo Autonomous Coding have a free plan? Yes: the Free pilot plan is free.
What does Cleo Autonomous Coding integrate with? 7 integrations, including Epic, Oracle Cerner, athenahealth, NextGen and eClinicalWorks.
Who is Cleo Autonomous Coding built for? Mid-market companies and enterprises (our editorial estimate).
Cleo Autonomous Coding pros and cons
- Where it wins
- Links every assigned code to supporting chart text
- Supports professional-fee and facility coding
- Integrates with seven named EHR platforms
- Where it doesn't
- Commercial pricing requires a sales conversation
- Focuses on emergency and hospital medicine
- Cloud deployment and email support only
Cleo Autonomous Coding fact sheet, pricing and score →
Advertiser disclosure: iTechGuides is reader-supported. Vendors can pay for top positions in our rankings and for a place on other products' pages, and we may earn a commission when you click some links. Bought places stand at the number bought; this page and our disclosure say so. Paying vendors may get a fuller, more detailed review from our editors, and that review can change their score. How we rank.
Last updated · How we research and update