Do these 3 things before closing this tab:
1Repair Windows errors before they cause bigger problems2Scan for outdated or missing drivers - takes under a minute3Clear out junk files and repair common Windows errorsiTechGuides is reader-supported. When you buy through links on our site, we may earn an affiliate commission. As an Amazon Associate I earn from qualifying purchases. Learn more
Two stories in STAT’s October 1, 2026, Pharmalittle roundup concern a planned Medicare payment model and early results for an experimental obesity-drug combination. CMS’s GLOBE model is limited to certain drugs covered by Original Medicare Part B and selected geographic areas; it is not a general price cap on Medicare prescriptions. In Lilly’s mid-stage study, participants with obesity and type 2 diabetes who stayed on the highest-dose Zepbound–eloralintide combination lost 23.3% of their weight over 48 weeks, according to STAT. The roundup also flags an HHS announcement about using AI in clinical trials, but its accessible text does not explain the initiatives.
What Medicare’s GLOBE model would change
GLOBE stands for Global Benchmark for Efficient Drug Pricing. The Centers for Medicare & Medicaid Services (CMS) describes it as a mandatory model testing a different way to calculate inflation rebates for certain separately payable drugs and biological products under Original Medicare Part B. These medicines are generally administered in clinical settings. The calculation would use international drug-price information.
That scope matters: GLOBE does not cover every drug or every Medicare prescription. CMS says it expects the model to lower out-of-pocket costs for beneficiaries included in it while preserving or improving care quality. The administration’s CMS administrator, Dr. Mehmet Oz, said, “Medicare Part B patients and American taxpayers have paid significantly more for prescription medications than people in comparable countries.” CMS’s September 30, 2026 announcement describes the model and its aims.
Outdated Drivers Are Slowing You Down
One free scan finds every outdated or missing driver and matches the right update for your exact hardware.Free scan · exact hardware matchPC Slower Than It Used to Be?
A free scan shows the junk files, broken settings and background clutter dragging Windows down - then fixes them in one click.Free scan · Windows 10 & 11STAT reports that the final rule covers four companies and is expected to deliver 96% less savings than the initial proposal. Those are STAT’s comparisons, not figures identified in the cited CMS materials as agency estimates. STAT also reports that the companion GUARD pilot remains proposed. STAT’s October 1 roundup is subscriber-gated beyond its accessible summary.
#1 Best Overall
- 12 MONTH WEIGHT LOSS TRACKER Track your weight loss journey over 12 months with a guided journal designed for recording pounds lost, body measurements, goals and progress.
- POUNDS LOST & BODY MEASUREMENTS Includes 10, 20, 30, 50 and 100 pounds lost trackers, plus body measurement tracking to help you visually follow your progress over time.
- MONTHLY STEP & FITNESS TRACKERS Plan and record movement with monthly step trackers and monthly fitness planner pages, ideal for building consistency around activity and fitness goals.
- VITAMINS, SUPPLEMENTS & REFLECTIONS Includes vitamins and supplements trackers, plus goals and reflections sections to help you stay organised and review your progress throughout the year.
- CHALLENGES TO KEEP YOU MOTIVATED Features 30 day, 12 week and 52 week challenges, giving you different ways to stay focused and create momentum across your weight loss journey.
Who may be affected, and when
CMS says selected geographic areas encompass approximately 25% of Original Medicare beneficiaries. That is the agency’s estimate of the model’s geographic reach—not a claim that one quarter of all people with Medicare, or all beneficiaries nationwide, will receive lower costs. CMS says people do not need to enroll or take action, and the rule is intended to leave Medicare coverage and provider choice unchanged.
Three dates describe different parts of the policy:
Rank #2
- FOOD JOURNAL FOR HEALTHY - A food journal to tracks daily dietary and nutritional intake for women/men. It will help you stay healthy, get motivated, get rid of bad habits, and achieve your weight loss goals. Focus on your health and eat healthy, this food tracker is all about what you want to improve.
- ACHIEVE GOALS - This fitness and nutrition journal helps you set big goals, break them down into monthly milestones, and work relentlessly toward them. At the end of each month, you will complete a monthly review to reflect your progress.
- UNDATED 6 MONTH MEAL PLANNER - This is a food diary that tracks meals and exercise last for 6 month. Keep daily records of calories, sleep time, water, weight, body fat, and activity. The monthly record can help you pay attention to your health and notice how changing your diet and lifestyle affects how you feel.
- ADDITIONAL - Lovely patterns created by hardcover, high quality of size 5.8" x 8.3", There are 3 sheets colorful stickers to help you plan and stay motivated to continue using this daily journal. What's more, the food journal with 3 ribbon bookmark, elastic band, pen holder and inner pocket for easy use.
- GUARANTEE - If you have any problems with this food journal, please contact us and we will help you solve promptly!
| Milestone | Scheduled date | What it means |
|---|---|---|
| Rule effective date | November 30, 2026 | The regulations take effect; this is not the model’s start date. |
| GLOBE model period | January 1, 2027–March 31, 2032 | The model’s scheduled operating period. |
| Reduced coinsurance for selected beneficiaries | April 1, 2027–March 31, 2032 | The scheduled period for the coinsurance change in selected areas. |
CMS says rebate invoicing and reconciliation continue into 2034, after the model period ends. The Federal Register rule sets out the effective date and regulatory details; CMS provides the model schedule and beneficiary information in its announcement.
What Lilly’s Zepbound–eloralintide study reported
The roundup describes a mid-stage study in people with obesity and type 2 diabetes. It compared Lilly’s Zepbound, a GLP-1 drug, with eloralintide, an investigational drug that targets the amylin hormone, and a combination of the two.
At 48 weeks, STAT reports these weight-loss figures:
| Treatment | Reported weight loss | Qualification |
|---|---|---|
| Highest-dose Zepbound plus eloralintide | 23.3% | Among participants who remained on the combination. |
| Zepbound alone | 14.8% | STAT’s reported 48-week comparison. |
| Highest-dose eloralintide alone | 11.1% | STAT’s reported 48-week comparison. |
The 23.3% result is specifically for participants who stayed on the highest-dose combination; it should not be read as an outcome for everyone who began treatment or as a guaranteed result for an individual. STAT flags high discontinuation as a tolerability concern, but its accessible summary does not provide a discontinuation rate or a detailed adverse-event breakdown. Eloralintide and the combination are investigational in this reporting, and these results do not establish regulatory approval, long-term outcomes, or effectiveness for every patient. The figures are reported in STAT’s roundup; an original trial publication and full protocol are not available in the cited material.
Rank #4
- 150-day/5-month food and fitness journal with measuring tape: this fitness journal allows you to record up to 150 days of fitness and diet data, ensuring you stay on track with your health goals. The measuring tape helps you to track your body dimensions and detailed tracking system helps you monitor progress and make necessary adjustments to your routine
- Structured goal setting and achievement: the 2 goal pages of fitness planner has 10 sections for setting clear objectives, start and end dates, detailed plans, and results. The workout journal also features a reward section to motivate you to achieve your fitness milestones
- Body dimension contrasts by table, photos and chart: the body dimension contrasts can be shown by figures, photos, and progress curves. This visual representation allows you to see tangible changes in your physique over time, providing motivation and a clear sense of achievement
- Integrated calendar and daily tracking: the 2-page undated calendar of weight loss journal provides a monthly overview with daily completion marks and progress curves. The daily tracking pages allow you to log specific exercises, calories burned, and meal calorie intake. This integrated system helps you maintain a consistent routine and stay accountable to your fitness and nutrition goals
- User-friendly design, durable material: the 9.5'' * 7'' fitness journal for women is easy to carry and use, with a waterproof and sweat-proof PP material cover and ink-resistant 100gsm thick paper inside. The elastic band keeps the workout planner closed to keep your data private and organized. Double sided pockets are designed for cards, guidebooks, etc.
What is known about HHS and AI in clinical trials
STAT’s subtitle says HHS announced initiatives to use AI to speed clinical trials. The accessible article text does not identify the initiatives, responsible offices, technologies, timeline, or evidence of impact. Those details therefore cannot be established from the available account.
The Tool Desk
Outbyte Driver Updater FREEScan for outdated or missing drivers - takes under a minuteDriver Scan →Outbyte PC Repair FREERepair Windows errors before they cause bigger problemsFix Now →Quick Recap
Best Value
- SMASH YOUR PB'S - Achieve the performance and physique you've always wanted with Nextnoid daily workout journal! Effectively track both daily and weekly workout goals upto 8 months as meticulously as you desire, plan next week's workouts, and celebrate your success with ease. Stay focused!
- GET FITTER, FASTER - Take control of your health and fitness journey and accelerate your results with our fitness planner for women and men! This exercise diary provides you with a proven system to build muscle, improve strength or just be healthier. What gets measured, improves!
- SIMPLE AND CLEAR - Setting yourself up for success has never been easier! Our personal workout book takes the thought and effort out of staying disciplined and accountable with a clear incremental progress system, bigger fonts for easy reading and enough space to jot down everything.
- CAREFULLY CRAFTED - Made with functionality and also long-lasting durability in mind with size 5.7x8.3 in, this fit log journal is tough enough to withstand the rigors of the gym floor, running trail and even the kitchen! Premium thick 120gsm pages and a sweat and tear-proof outer match your grit!
- PERFECT GIFT - Show the fitness enthusiast in your life just how much you care with this workout tracker notebook! Also ideal for the beginner who dreams of being in shape, this fitness training journal could be the motivation they need to kickstart their health and wellness journey!
Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Amazon at the time of purchase will apply.
