Head-to-head · Computer Security
Microsoft Defender for Business vs Trellix Endpoint Security
Microsoft Defender for Business leads on 0 checks, Trellix Endpoint Security on 0, and 2 are even. Who comes out ahead on the 2 yes/no, price and count checks where we have data for both products. The editor score weighs everything else too.
Our verdict
- Highest scoreMicrosoft Defender for Business · 8.7/10
- Free trialonly Microsoft Defender for Business
- Most featuresMicrosoft Defender for Business · 1 of 4
Microsoft Defender for Business scores higher on our rubric for computer security: 8.7 against 8.4 out of 10; our editors rank them #6 and #8.
Microsoft Defender for Business is the better fit for small businesses already using Microsoft tools. Trellix Endpoint Security is the better fit for mid-size and large teams managing endpoints centrally.
- Microsoft Defender for Business fits best
Small businesses already using Microsoft tools
- Trellix Endpoint Security fits best
Mid-size and large teams managing endpoints centrally
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Side by side
| Feature | Microsoft Defender for Business 8.7/10 Visit ↗ | Trellix Endpoint Security 8.4/10 Visit ↗ |
|---|---|---|
| At a glance | ||
| Editor score | 8.7 | 8.4 |
| Ranking | #6 in Computer Security | #8 in Computer Security |
| Best for | Small businesses already using Microsoft tools | Mid-size and large teams managing endpoints centrally |
| Pricing model | Paid | Paid |
| Starting price | $3/user/mo | Pricing on request |
| Free plan | — | Not checked yet |
| Free trial | 30 days | — |
| Deployment | Cloud, Mobile | Cloud, Self-hosted |
| Platforms | Web, Windows, macOS, iOS, Android | Windows, macOS, Linux |
| Support | Docs | Tickets |
| Integrations | 4 integrations | 4 integrations |
| Built for | Small business, Mid-market | Mid-market, Enterprise |
| Features Microsoft Defender for Business 1/4 · Trellix Endpoint Security 0/4 | ||
| Real-time protection | Not checked yet | Not checked yet |
| Ransomware protection | ✓ (best) | Not checked yet |
| Vulnerability scanning | Not checked yet | Not checked yet |
| Central management | Not checked yet | Not checked yet |
| Specs | ||
| Deployment | Not checked yet | Not checked yet |
| Platform support | Not checked yet | Not checked yet |
| Our review | ||
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| Cons |
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| Our verdict | Microsoft Defender for Business is an endpoint security service for small and medium-sized businesses with up to 300 users. It combines next-generation antivirus, ransomware protection, endpoint detection and response, vulnerability… Read the review → |
Trellix Endpoint Security is an endpoint protection platform for organizations managing clients, servers, and network-attached storage across varied environments. Its feature set is aimed at mid-size and large teams that need centralized… Read the review → |
Strengths and trade-offs
Microsoft Defender for Business — where it wins
- Automatic disruption for in-progress ransomware attacks
- Covers Windows, macOS, iOS and Android devices
- Includes EDR, investigation, remediation and vulnerability management
Where it doesn't
- Annual billing applies to the $3-per-user monthly price
- The 30-day trial requires a payment card
- Support channels are limited to documentation
Trellix Endpoint Security — where it wins
- Combines behavioral detection, machine-learning prevention, and exploit blocking
- Centralizes policy management through ePolicy Orchestrator
- Covers clients, servers, and NAS with device and application controls
Where it doesn't
- Pricing requires contacting sales
- Mobile protection is a separate Trellix product
- Ticket support may not suit teams needing other support channels
- Microsoft Defender for Business8.7/10 · 30-day trial
A Microsoft-integrated endpoint security suite at $3 per user monthly, billed annually.
Visit MicrosoftFull verdict → - Trellix Endpoint Security8.4/10 · Pricing on request
Centralized endpoint protection for teams managing varied devices and environments.
Visit TrellixFull verdict →
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Reviewed by iTechGuides Editors · Editorial team · Updated Oct 2026
Last updated · How we research and update