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Head-to-head · AI Clinical Decision Support Software

ClinicalKey AI vs ORAYA

  • Updated Nov 2026
  • Both researched from official sources
  • 6 checks side by side
Higher score ClinicalKey AI #2 in AI Clinical Decision Support Software 9.0/10 90-day trial Free trial✓ 2 of 6 features Visit ClinicalKey AI
ORAYA #6 in AI Clinical Decision Support Software 7.9/10 Pricing on request ✓ 5 of 6 features Visit ORAYA

ClinicalKey AI leads on 0 checks, ORAYA on 0, and 6 are even. Who comes out ahead on the 6 yes/no, price and count checks where we have data for both products. The editor score weighs everything else too.

Our verdict

  • Highest scoreClinicalKey AI · 9.0/10
  • Free trialonly ClinicalKey AI
  • Most featuresORAYA · 5 of 6

ClinicalKey AI scores higher on our rubric for ai clinical decision support software: 9.0 against 7.9 out of 10; our editors rank them #2 and #6.

ClinicalKey AI is the better fit for clinicians who prioritize evidence-linked answers. ORAYA is the better fit for teams needing chart-aware clinical answers and treatment.

  • ClinicalKey AI fits best

    Clinicians who prioritize evidence-linked answers

  • ORAYA fits best

    Teams needing chart-aware clinical answers and treatment

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Side by side

Feature ClinicalKey AI 9.0/10 Visit ↗ ORAYA 7.9/10 Visit ↗
At a glance
Editor score 9.0 7.9
Ranking #2 in AI Clinical Decision Support Software #6 in AI Clinical Decision Support Software
Best for Clinicians who prioritize evidence-linked answers Teams needing chart-aware clinical answers and treatment
Pricing model Paid Paid
Starting price $349/user/yr Pricing on request
Free plan — Not checked yet
Free trial 90 days —
Deployment Cloud, Mobile Cloud, Mobile
Platforms Web, iOS, Android Web, iOS, Android
Support Docs Email
Compliance HIPAA, SSO/SAML HIPAA
Integrations 2 integrations 2 integrations
Built for Solo, Small business, Mid-market, Enterprise Small business, Mid-market, Enterprise
Features ClinicalKey AI 2/6 · ORAYA 5/6
Differential diagnosis Not checked yet ✓ (best)
Treatment recommendations Not checked yet ✓ (best)
Drug interaction support Not checked yet ✓ (best)
Clinical risk prediction Not checked yet Not checked yet
Evidence citations ✓ ✓
EHR integration ✓ ✓
Our review
Pros
  • Summarizes clinical sources with links to published evidence.
  • Can consider age, comorbidities, and medications when prompted.
  • Offers SMART on FHIR EHR access, API compatibility, and mobile apps.
  • Uses chart context for clinical questions and treatment options
  • Checks drug interactions and contraindications
  • Drafts structured visit notes for clinician review and signature
Cons
  • Individual Monthly costs $39 per month.
  • EHR workflow access depends on SMART on FHIR SSO.
  • The listed support channel is documentation.
  • Pricing and subscription terms are set by clinic agreement
  • Documentation drafts require clinician review and signature
  • HIPAA and SOC 2 compliance are pending
Our verdict

ClinicalKey AI from Elsevier is a clinical decision-support tool for clinicians seeking conversational access to medical references. Users can ask natural-language questions and follow up, receiving summarized answers linked to published…

Read the review →

ORAYA is a clinical AI platform for clinicians, pharmacy and PBM teams, and clinical researchers. It answers questions about dosing, safety, and treatment using medical literature and FDA sources, with linked citations and evidence…

Read the review →
  1. ClinicalKey AIAI Clinical Decision Support Software 9.090-day trial
  2. ORAYAAI Clinical Decision Support Software 7.9Pricing on request

Strengths and trade-offs

  • ClinicalKey AI — where it wins

    • Summarizes clinical sources with links to published evidence.
    • Can consider age, comorbidities, and medications when prompted.
    • Offers SMART on FHIR EHR access, API compatibility, and mobile apps.

    Where it doesn't

    • Individual Monthly costs $39 per month.
    • EHR workflow access depends on SMART on FHIR SSO.
    • The listed support channel is documentation.

  • ORAYA — where it wins

    • Uses chart context for clinical questions and treatment options
    • Checks drug interactions and contraindications
    • Drafts structured visit notes for clinician review and signature

    Where it doesn't

    • Pricing and subscription terms are set by clinic agreement
    • Documentation drafts require clinician review and signature
    • HIPAA and SOC 2 compliance are pending

More comparisons

All AI clinical decision support software comparisons → · Full ranking →

Reviewed by iTechGuides Editors · Editorial team · Updated Nov 2026

Last updated · How we research and update