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The EU prohibited trimethylbenzoyl diphenylphosphine oxide (TPO) in cosmetics because it is classified as a category 1B substance toxic for reproduction. The prohibition has applied since 1 September 2025. It targets cosmetics containing TPO—not all gel nail polish, gel manicures, UV lamps, or artificial nail systems.

What is TPO, and where was it used?

TPO is the common name for the cosmetic ingredient listed as Trimethylbenzoyl Diphenylphosphine Oxide. The EU regulation identifies it chemically as diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide and gives its CAS number as 75980-60-8. It was used in artificial nail systems, including some gel nail products.

Why did the EU prohibit TPO?

The reason stated in Commission Regulation (EU) 2025/877 is TPO’s classification as a category 1B CMR substance—specifically, toxic for reproduction. The regulation says: “In light of the classification of ‘Trimethylbenzoyl Diphenylphosphine Oxide’ as a CMR substance of category 1B (Toxic for Reproduction), that substance should no longer be allowed in cosmetic products.” Read the European Commission regulation.

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The regulation cites Commission Delegated Regulation (EU) 2024/197 as the classification instrument. It changes the cosmetics ingredient rules; it does not publish a numerical estimate of consumer risk. The category is the regulatory reason for the prohibition, not a percentage measure of the risk from a particular manicure.

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What changed in the EU rules?

Before the amendment, TPO was listed among restricted cosmetic ingredients. Its allowance was limited to professional use in artificial nail systems, with a maximum concentration of 5%. Regulation (EU) 2025/877 deleted that restricted-use entry and added TPO to the list of substances prohibited in cosmetics.

The regulation is dated 12 May 2025, and the prohibition applies from 1 September 2025. From that date, the former professional-use allowance no longer applies to cosmetic products containing TPO.

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  • Safety Warning: Avoid eye & mouth contact. Rinse immediately with water if contact occurs. Discontinue use & seek medical help if discomfort persists. Your safety is paramount
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Does this mean gel polish or gel manicures are banned?

No. The rule concerns the ingredient TPO in cosmetics. It does not ban every gel polish, every artificial nail system, or gel manicures as a category. A product’s status depends on its ingredients and the applicable EU requirements; the regulation alone does not establish whether a particular product is compliant.

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If you are checking a product, look for “Trimethylbenzoyl Diphenylphosphine Oxide” on its ingredient information. A product described as “TPO-free gel nail polish” is a useful category to search for, but that phrase by itself does not verify a specific formula or its current EU compliance. Check the product’s current ingredient list and relevant requirements rather than relying only on a label or marketing claim.

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What consumers and nail professionals should take from the change

  • Ingredient, not product category: TPO is prohibited in EU cosmetics; gel products without TPO are not banned by this measure.
  • Professional use is not an exception: the previous 5% maximum applied to professional use in artificial nail systems, but that allowance was removed.
  • The effective date has passed: the prohibition applies from 1 September 2025.
  • Do not infer a specific product’s status: check the current ingredient list and applicable EU rules.

Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Amazon at the time of purchase will apply.