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Head-to-head · Document Control Software

Ketryx vs MasterControl Document Control

  • Updated Oct 2026
  • Both researched from official sources
  • 5 checks side by side
Higher score Ketryx #1 in Document Control Software 9.4/10 Free plan Free plan✓ 4 of 6 features Visit Ketryx
MasterControl Document Control #8 in Document Control Software 8.4/10 Pricing on request ✓ 2 of 6 features Visit MasterControl

Ketryx leads on 0 checks, MasterControl Document Control on 0, and 5 are even. Who comes out ahead on the 5 yes/no, price and count checks where we have data for both products. The editor score weighs everything else too.

Our verdict

  • Highest scoreKetryx · 9.4/10
  • Free planonly Ketryx
  • Most featuresKetryx · 4 of 6

Ketryx scores higher on our rubric for document control software: 9.4 against 8.4 out of 10; our editors rank them #1 and #8.

Ketryx is the better fit for regulated product teams needing traceability. MasterControl Document Control is the better fit for established quality teams needing document workflows.

  • Ketryx fits best

    Regulated product teams needing traceability

  • MasterControl Document Control fits best

    Established quality teams needing document workflows

Advertiser disclosure: iTechGuides is reader-supported. Vendors can pay for top positions in our rankings and for a place on other products' pages, and we may earn a commission when you click some links. Bought places stand at the number bought; this page and our disclosure say so. Paying vendors may get a fuller, more detailed review from our editors, and that review can change their score. How we rank.

Side by side

Feature Ketryx 9.4/10 Visit ↗ MasterControl Document Control 8.4/10 Visit ↗
At a glance
Editor score 9.4 8.4
Ranking #1 in Document Control Software #8 in Document Control Software
Best for Regulated product teams needing traceability Established quality teams needing document workflows
Pricing model Free plan + paid Paid
Starting price — Pricing on request
Free plan ✓ (best) Not checked yet
Free trial — —
Deployment Cloud Cloud
Platforms Web Web
Integrations 12 integrations 4 integrations
Built for Small business, Mid-market, Enterprise Small business, Mid-market, Enterprise
Features Ketryx 4/6 · MasterControl Document Control 2/6
Revision history ✓ (best) Not checked yet
Approval workflows ✓ (best) Not checked yet
Audit trail ✓ ✓
Electronic signatures ✓ ✓
Role-based access Not checked yet Not checked yet
Document expiry controls Not checked yet Not checked yet
Our review
Pros
  • Part 11 audit trails and biometric electronic signatures
  • Traceability across requirements, risks, designs, and tests
  • AI-assisted impact analysis plus extensive development integrations
  • Automatic revision control with approval routing and electronic signatures
  • Time-stamped audit trails, status tracking, search and retrieval
  • Integrations with ERP, LIMS, accounting and human resources systems
Cons
  • Paid plan pricing requires contacting sales
  • Free access is limited to eligible pre-market companies
  • Available as a web platform only
  • Pricing requires a contact-sales process rather than listed plans
  • Web-only access may not fit teams requiring other platforms
  • Storage and workflow quotas require clarification before purchase
Our verdict

Ketryx is a cloud document-control platform for medical-device, life-sciences, and other regulated product teams. It brings controlled documents, version comparison, approvals, electronic signatures, audit trails, traceability, design…

Read the review →

MasterControl Document Control is a web-based document management solution within MasterControl Quality Excellence. It is designed for regulated life sciences organizations that need controlled document workflows across review, approval,…

Read the review →
  1. KetryxDocument Control Software 9.4Free plan
  2. MasterControl Document ControlDocument Control Software 8.4Pricing on request

Strengths and trade-offs

  • Ketryx — where it wins

    • Part 11 audit trails and biometric electronic signatures
    • Traceability across requirements, risks, designs, and tests
    • AI-assisted impact analysis plus extensive development integrations

    Where it doesn't

    • Paid plan pricing requires contacting sales
    • Free access is limited to eligible pre-market companies
    • Available as a web platform only

  • MasterControl Document Control — where it wins

    • Automatic revision control with approval routing and electronic signatures
    • Time-stamped audit trails, status tracking, search and retrieval
    • Integrations with ERP, LIMS, accounting and human resources systems

    Where it doesn't

    • Pricing requires a contact-sales process rather than listed plans
    • Web-only access may not fit teams requiring other platforms
    • Storage and workflow quotas require clarification before purchase
  • Ketryx9.4/10 · Free plan

    A broad document-control platform for regulated teams that need auditable traceability.

    Visit KetryxFull verdict →
  • MasterControl Document Control8.4/10 · Pricing on request

    A workflow-focused document control system for established regulated quality teams.

    Visit MasterControlFull verdict →

More comparisons

All document control software comparisons → · Full ranking →

Reviewed by iTechGuides Editors · Editorial team · Updated Oct 2026

Last updated · How we research and update